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Adipose tissue lipolytic inhibition enhances the glucoregulatory properties of exercise in type 2 diabetes patients
Hansen, Dominique Verboven, Kenneth van Dijk, Jan Willem Zorenc, Antoine H. Minten, Lennert Smeets, Kevin Verdijk, Lex B. Van Loon, Luc
Hansen, Dominique
Verboven, Kenneth
van Dijk, Jan Willem
Zorenc, Antoine H.
Minten, Lennert
Smeets, Kevin
Verdijk, Lex B.
Van Loon, Luc
Abstract
Aims:
Exercise combined with adipose tissue lipolytic inhibition augments intramuscular lipid and glycogen use in type 2 diabetes patients. The present study investigates the impact of adipose tissue lipolytic inhibition during exercise on subsequent postprandial glycemic control in type 2 diabetes patients.
Methods:
Fourteen male type 2 diabetes patients (age 65 ± 2 years, HbA1c 6.7 ± 0.1% (50 ± 2 mmol/mol)) participated in a double-blind placebo-controlled randomized cross-over study in which subjects performed endurance-type exercise after being administered 250 mg of a nicotinic acid analogue (acipimox; ACP) or a placebo (PLA). A control experiment was included in which no exercise was performed (CON).
Results:
Sixty minutes of endurance-type exercise (at 45% Wpeak) did not significantly lower circulating plasma glucose and insulin excursions in PLA when compared with CON (P = .300). Acipimox administration strongly reduced circulating plasma FFA concentrations during exercise (P < .001). Circulating plasma glucose and insulin excursions were substantially lower during 7.5 h of recovery from exercise (i.e. postprandial) in ACP when compared with either CON (P = .041 and P = .002, respectively) or PLA (P = .009 and P = .001, respectively).
Conclusions:
Collectively, exercise with adipose tissue lipolytic inhibition reduces postprandial blood glucose and insulin excursions and, as such, further improves glycemic control in male type 2 diabetes patients.
Keywords
Exercise, metabolism, physiology, sedentary living
Date
2018
Type
Journal article
Journal
European Journal of Sport Science
Book
Volume
18
Issue
9
Page Range
1245-1254
Article Number
ACU Department
Centre for Exercise and Nutrition
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled