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Prenatal and childhood traffic-related air pollution exposure and telomere length in European children: The HELIX Project
Clemente, Diana B. P. Vrijheid, Martine Martens, Dries S. Bustamante, Mariona Chatzi, Leda Danileviciute, Asta de Castro, Montserrat Grazuleviciene, Regina Gutzkow, Kristine B. Lepeule, Johanna
Clemente, Diana B. P.
Vrijheid, Martine
Martens, Dries S.
Bustamante, Mariona
Chatzi, Leda
Danileviciute, Asta
de Castro, Montserrat
Grazuleviciene, Regina
Gutzkow, Kristine B.
Lepeule, Johanna
Author
Clemente, Diana B. P.
Vrijheid, Martine
Martens, Dries S.
Bustamante, Mariona
Chatzi, Leda
Danileviciute, Asta
de Castro, Montserrat
Grazuleviciene, Regina
Gutzkow, Kristine B.
Lepeule, Johanna
Maitre, Lea
McEachan, Rosie R. C.
Robinson, Oliver
Schwarze, Per E.
Tamayo, Ibon
Vafeiadi, Marina
Wright, John
Slama, Remy
Nieuwenhuijsen, Mark
Nawrot, Timothy S.
Vrijheid, Martine
Martens, Dries S.
Bustamante, Mariona
Chatzi, Leda
Danileviciute, Asta
de Castro, Montserrat
Grazuleviciene, Regina
Gutzkow, Kristine B.
Lepeule, Johanna
Maitre, Lea
McEachan, Rosie R. C.
Robinson, Oliver
Schwarze, Per E.
Tamayo, Ibon
Vafeiadi, Marina
Wright, John
Slama, Remy
Nieuwenhuijsen, Mark
Nawrot, Timothy S.
Abstract
Background: Telomere length is a molecular marker of biological aging. Objective: Here we investigated whether early-life exposure to residential air pollution was associated with leukocyte telomere length (LTL) at 8 y of age. Methods: In a multicenter European birth cohort study, HELIX (Human Early Life Exposome) ( n = 1,396 ), we estimated prenatal and 1-y childhood exposure to nitrogen dioxide (NO 2 ), particulate matter with aerodynamic diameter ≤ 2.5μ m (PM 2.5 ), and proximity to major roads. Average relative LTL was measured using quantitative real-time polymerase chain reaction (qPCR). Effect estimates of the association between LTL and prenatal, 1-y childhood air pollution, and proximity to major roads were calculated using multiple linear mixed models with a random cohort effect and adjusted for relevant covariates. Results: LTL was inversely associated with prenatal and 1-y childhoodNO 2 andPM 2.5 exposures levels. Each standard deviation (SD) increase in prenatalNO 2 was associated with a − 1.5 % (95% CI: − 2.8 , − 0.2 ) change in LTL. PrenatalPM 2.5 was nonsignificantly associated with LTL ( − 0.7 % per SD increase; 95% CI: − 2.0 , 0.6). For each SD increment in 1-y childhoodNO 2 andPM 2.5 exposure, LTL shortened by − 1.6 % (95% CI: − 2.9 , − 0.4 ) and − 1.4 % (95% CI: − 2.9 , 0.1), respectively. Each doubling in residential distance to nearest major road during childhood was associated with a 1.6% (95% CI: 0.02, 3.1) lengthening in LTL. Conclusion: Lower exposures to air pollution during pregnancy and childhood were associated with longer telomeres in European children at 8 y of age. These results suggest that reductions in traffic-related air pollution may promote molecular longevity, as exemplified by telomere length, from early life onward.
Keywords
Date
2019
Type
Journal article
Journal
Environmental Health Perspectives
Book
Volume
127
Issue
8
Page Range
1-8
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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DOI
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License
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Controlled