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Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression
Larivière, Sara Royer, Jessica Rodríguez-Cruces, Raúl Paquola, Casey Caligiuri, Maria Eugenia Gambardella, Antonio Concha, Luis Keller, Simon S. Cendes, Fernando Yasuda, Clarissa L.
Larivière, Sara
Royer, Jessica
Rodríguez-Cruces, Raúl
Paquola, Casey
Caligiuri, Maria Eugenia
Gambardella, Antonio
Concha, Luis
Keller, Simon S.
Cendes, Fernando
Yasuda, Clarissa L.
Author
Larivière, Sara
Royer, Jessica
Rodríguez-Cruces, Raúl
Paquola, Casey
Caligiuri, Maria Eugenia
Gambardella, Antonio
Concha, Luis
Keller, Simon S.
Cendes, Fernando
Yasuda, Clarissa L.
Bonilha, Leonardo
Gleichgerrcht, Ezequiel
Focke, Niels K.
Domin, Martin
von Podewills, Felix
Langner, Soenke
Rummel, Christian
Wiest, Roland
Martin, Pascal
Kotikalapudi, Raviteja
O’Brien, Terence J.
Sinclair, Benjamin
Vivash, Lucy
Desmond, Patricia M.
Lui, Elaine
Vaudano, Anna Elisabetta
Meletti, Stefano
Tondelli, Manuela
Alhusaini, Saud
Doherty, Colin P.
Cavalleri, Gianpiero L.
Delanty, Norman
Kälviäinen, Reetta
Jackson, Graeme D.
Kowalczyk, Magdalena
Mascalchi, Mario
Semmelroch, Mira
Thomas, Rhys H.
Soltanian-Zadeh, Hamid
Davoodi-Bojd, Esmaeil
Zhang, Junsong
Winston, Gavin P.
Griffin, Aoife
Singh, Aditi
Tiwari, Vijay K.
Kreilkamp, Barbara A. K.
Lenge, Matteo
Guerrini, Renzo
Hamandi, Khalid
Foley, Sonya
Rüber, Theodor
Weber, Bernd
Depondt, Chantal
Absil, Julie
Carr, Sarah J. A.
Abela, Eugenio
Richardson, Mark P.
Devinsky, Orrin
Severino, Mariasavina
Striano, Pasquale
Tortora, Domenico
Kaestner, Erik
Hatton, Sean N.
Vos, Sjoerd B.
Caciagli, Lorenzo
Duncan, John S.
Whelan, Christopher D.
Thompson, Paul M.
Sisodiya, Sanjay M.
Bernasconi, Andrea
Labate, Angelo
McDonald, Carrie R.
Bernasconi, Neda
Bernhardt, Boris C.
Royer, Jessica
Rodríguez-Cruces, Raúl
Paquola, Casey
Caligiuri, Maria Eugenia
Gambardella, Antonio
Concha, Luis
Keller, Simon S.
Cendes, Fernando
Yasuda, Clarissa L.
Bonilha, Leonardo
Gleichgerrcht, Ezequiel
Focke, Niels K.
Domin, Martin
von Podewills, Felix
Langner, Soenke
Rummel, Christian
Wiest, Roland
Martin, Pascal
Kotikalapudi, Raviteja
O’Brien, Terence J.
Sinclair, Benjamin
Vivash, Lucy
Desmond, Patricia M.
Lui, Elaine
Vaudano, Anna Elisabetta
Meletti, Stefano
Tondelli, Manuela
Alhusaini, Saud
Doherty, Colin P.
Cavalleri, Gianpiero L.
Delanty, Norman
Kälviäinen, Reetta
Jackson, Graeme D.
Kowalczyk, Magdalena
Mascalchi, Mario
Semmelroch, Mira
Thomas, Rhys H.
Soltanian-Zadeh, Hamid
Davoodi-Bojd, Esmaeil
Zhang, Junsong
Winston, Gavin P.
Griffin, Aoife
Singh, Aditi
Tiwari, Vijay K.
Kreilkamp, Barbara A. K.
Lenge, Matteo
Guerrini, Renzo
Hamandi, Khalid
Foley, Sonya
Rüber, Theodor
Weber, Bernd
Depondt, Chantal
Absil, Julie
Carr, Sarah J. A.
Abela, Eugenio
Richardson, Mark P.
Devinsky, Orrin
Severino, Mariasavina
Striano, Pasquale
Tortora, Domenico
Kaestner, Erik
Hatton, Sean N.
Vos, Sjoerd B.
Caciagli, Lorenzo
Duncan, John S.
Whelan, Christopher D.
Thompson, Paul M.
Sisodiya, Sanjay M.
Bernasconi, Andrea
Labate, Angelo
McDonald, Carrie R.
Bernasconi, Neda
Bernhardt, Boris C.
Abstract
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms and macroscale connectomics remain unclear. This multisite ENIGMA-Epilepsy study examined whole-brain structural covariance networks in patients with epilepsy and related findings to postmortem epilepsy risk gene expression patterns. Brain network analysis included 578 adults with temporal lobe epilepsy (TLE), 288 adults with idiopathic generalized epilepsy (IGE), and 1328 healthy controls from 18 centres worldwide. Graph theoretical analysis of structural covariance networks revealed increased clustering and path length in orbitofrontal and temporal regions in TLE, suggesting a shift towards network regularization. Conversely, people with IGE showed decreased clustering and path length in fronto-temporo-parietal cortices, indicating a random network configuration. Syndrome-specific topological alterations reflected expression patterns of risk genes for hippocampal sclerosis in TLE and for generalized epilepsy in IGE. These imaging-transcriptomic signatures could potentially guide diagnosis or tailor therapeutic approaches to specific epilepsy syndromes.
Keywords
Date
2022
Type
Journal article
Journal
Nature Communications
Book
Volume
13
Issue
1
Page Range
1-16
Article Number
Article 4320
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open