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Cortical morphometry and neural dysfunction in Huntington’s disease : A review
Tan, Brendan Shishegar, Rosita Poudel, Govinda R. Fornito, Alex Georgiou-Karistianis, Nellie
Tan, Brendan
Shishegar, Rosita
Poudel, Govinda R.
Fornito, Alex
Georgiou-Karistianis, Nellie
Abstract
Abstract
Numerous neuroimaging techniques have been used to identify biomarkers of disease progression in Huntington's disease (HD). To date, the earliest and most sensitive of these is caudate volume; however, it is becoming increasingly evident that numerous changes to cortical structures, and their interconnected networks, occur throughout the course of the disease. The mechanisms by which atrophy spreads from the caudate to these cortical regions remains unknown. In this review, the neuroimaging literature specific to T1-weighted and diffusion-weighted magnetic resonance imaging is summarized and new strategies for the investigation of cortical morphometry and the network spread of degeneration in HD are proposed. This new avenue of research may enable further characterization of disease pathology and could add to a suite of biomarker/s of disease progression for patient stratification that will help guide future clinical trials.
Keywords
cortical morphometry, Huntington's disease, network spread hypothesis, neuroimaging, neuronal dysfunction
Date
2021
Type
Journal article
Journal
European Journal of Neurology
Book
Volume
28
Issue
4
Page Range
1406-1419
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled