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The fifth element in drug design: Boron in medicinal chemistry
Kahlert, Jan Austin, Christopher J. D. Kassiou, Michael Rendina, Louis M.
Kahlert, Jan
Austin, Christopher J. D.
Kassiou, Michael
Rendina, Louis M.
Abstract
The unique chemistry of boron allows for the utilisation of novel building-blocks which are not traditionally found in medicinal chemistry. The pharmaceutical industry has begun to exploit boronic acid derivatives as new drugs and several research groups are also exploring 1,2-azaborines and icosahedral boranes known as carboranes as boron-based structural motifs, with great promise for innovative drug design. Recent advances in the medicinal chemistry of these three important boron moieties are highlighted and illustrated with selected examples.
Keywords
Date
2013
Type
Journal article
Journal
Australian Journal of Chemistry
Book
Volume
66
Issue
10
Page Range
1118-1123
Article Number
ACU Department
Collections
Relation URI
DOI
Source URL
Event URL
Open Access Status
License
File Access
Controlled