Circulating insulin-like growth factor-binding protein 3 levels, independent of insulin-like growth factor 1, associate with truncal fat and systolic blood pressure in South Asian and white European preschool children
Leena Patel Andrew Whatmore Jill Davies Narinder Bansal Avni Vyas Isla Gemmell John Oldroyd John Kennedy Cruickshank Peter Clayton
Leena Patel
Andrew Whatmore
Jill Davies
Narinder Bansal
Avni Vyas
Isla Gemmell
John Oldroyd
John Kennedy Cruickshank
Peter Clayton
Abstract
Aims: To study the effect of the insulin-like growth factor (IGF) system on growth, adiposity and systolic blood pressure (SBP) in early life in British-born South Asian (SA) and White European (WE) children. Methods: The effect of IGF-1 and insulin-like growth factor-binding protein 3 (IGFBP-3) over the first 4 years in 204 healthy SA and WE children was investigated by mixed linear regression modelling. This enabled inclusion of all follow-up observations and adjustment for repeated measures. Results: At birth, SA babies were shorter and lighter than WE babies. Over 4 years, SA ethnicity was associated with lower height, weight and body mass index (BMI) standard deviation score (SDS), higher subscapular/triceps skinfold thickness (Ss/Tr SFT) and lower SBP (all p < 0.01). IGF-1 was associated with greater height (p = 0.03), weight (p < 0.001) and BMI SDS (p < 0.001), and IGFBP-3 with greater weight SDS (p < 0.001), BMI SDS (p = 0.001), Ss/Tr SFT (p = 0.003) and SBP (p = 0.023). Conclusions: Over this first 4-year period of life, SA ethnicity was associated with being shorter, lighter, having more superficial truncal adiposity and lower SBP. IGFBP-3 (and not IGF-1) was independently associated with both superficial truncal adiposity and SBP, suggesting that IGFBP-3 is a potential metabolic and cardiovascular marker in healthy children in the early years of life.
Keywords
insulin-like growth factor 1, insulin-like growth factor-binding protein 3, truncal fat, systolic blood pressure, ethnicity
Date
2014
Type
Journal article
Journal
Hormone Research in Paediatrics: from developmental endocrinology to clinical research
Book
Volume
81
Issue
2
Page Range
109-117