Molecular responses to strength and endurance training: Are they incompatible?
Hawley, John Alan
Hawley, John Alan
Author
Abstract
Simultaneously training for both strength and endurance results in a compromised adaptation, compared with training for either exercise mode alone. This has been variously described as the concurrent training effect or the interference effect. It now appears that the genetic and molecular mechanisms of adaptation induced by resistance- and endurance-based training are distinct, with each mode of exercise activating and (or) repressing specific subsets of genes and cellular signalling pathways. This brief review will summarize our current understanding of the molecular responses to strength and endurance training, and will examine the molecular evidence for an interference effect when concurrent training is undertaken. A better understanding of the activation and interaction of the molecular pathways in response to these different modes of exercise will permit sport scientists to develop improved training programs capable of maximizing both strength and endurance.
Keywords
Akt, AMPK, endurance training, mTOR, PGC-1, strength training, skeletal muscle adaptations
Date
2009
Type
Journal article
Journal
Applied Physiology, Nutrition and Metabolism
Book
Volume
34
Issue
3
Page Range
355-361
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences