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Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates : A randomized control trial
Parr, Evelyn B. Kouw, Imre W. K. Wheeler, Michael J. Radford, Bridget E. Hall, Rebecca C. Senden, Joan M. Goessens, Joy P. B. Van Loon, Luc J. C. Hawley, John A.
Parr, Evelyn B.
Kouw, Imre W. K.
Wheeler, Michael J.
Radford, Bridget E.
Hall, Rebecca C.
Senden, Joan M.
Goessens, Joy P. B.
Van Loon, Luc J. C.
Hawley, John A.
Abstract
Objective
This study aimed to assess the impact of time-restricted eating (TRE) on integrated skeletal muscle myofibrillar protein synthesis (MyoPS) rates in males with overweight/obesity.
Methods
A total of 18 healthy males (age 46 ± 5 years; BMI: 30 ± 2 kg/m2) completed this exploratory, parallel, randomized dietary intervention after a 3-day lead-in diet. Participants then consumed an isoenergetic diet (protein: ~1.0 g/kg body mass per day) following either TRE (10:00 a.m. to 6:00 p.m.) or an extended eating control (CON; 8:00 a.m. to 8:00 p.m.) protocol for 10 days. Integrated MyoPS rates were measured using deuterated water administration with repeated saliva, blood, and muscle sampling. Secondary measures included continuous glucose monitoring and body composition (dual-energy x-ray absorptiometry).
Results
There were no differences in daily integrated MyoPS rates (TRE: 1.28% ± 0.18% per day, CON: 1.26% ± 0.22% per day; p = 0.82) between groups. From continuous glucose monitoring, 24-hour total area under the curve was reduced following TRE (−578 ± 271 vs. CON: 12 ± 272 mmol/L × 24 hours; p = 0.001). Total body mass declined (TRE: −1.6 ± 0.9 and CON: −1.1 ± 0.7 kg; p < 0.001) with no differences between groups (p = 0.22). Lean mass loss was greater following TRE compared with CON (−1.0 ± 0.7 vs. −0.2 ± 0.5 kg, respectively; p = 0.01).
Conclusion
Consuming food within an 8-hour time-restricted period does not lower daily MyoPS rates when compared with an isoenergetic diet consumed over 12 hours. Future research should investigate whether these results translate to free-living TRE.
Keywords
Date
2023
Type
Journal article
Journal
Obesity
Book
Volume
31
Issue
S1
Page Range
116-126
Article Number
ACU Department
Centre for Exercise and Nutrition
Faculty of Health Sciences
School of Behavioural and Health Sciences
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
School of Behavioural and Health Sciences
Mary MacKillop Institute for Health Research
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY-NC-ND 4.0
File Access
Open