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Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels
Kwan, Johnny S. H. Hsu, Yi-Hsiang Cheung, Ching-Lung Dupuis, Josée Saint-Pierre, Aude Eriksson, Joel Handelman, Samuel K. Aragaki, Aaron K. Karasik, David Pramstaller, Peter P.
Kwan, Johnny S. H.
Hsu, Yi-Hsiang
Cheung, Ching-Lung
Dupuis, Josée
Saint-Pierre, Aude
Eriksson, Joel
Handelman, Samuel K.
Aragaki, Aaron K.
Karasik, David
Pramstaller, Peter P.
Author
Kwan, Johnny S. H.
Hsu, Yi-Hsiang
Cheung, Ching-Lung
Dupuis, Josée
Saint-Pierre, Aude
Eriksson, Joel
Handelman, Samuel K.
Aragaki, Aaron K.
Karasik, David
Pramstaller, Peter P.
Kooperberg, Charles
Lacroix, Andrea Z.
Larson, Martin G.
Lau, Kam-Shing
Lorentzon, Mattias
Pichler, Irene
Sham, Pak Chung
Taliun, Daniel
Vandenput, Liesbeth
Kiel, Douglas P.
Hicks, Andrew A.
Jackson, Rebecca D.
Ohlsson, Claes
Benjamin, Emelia J.
Kung, Annie Wai Chee
Hsu, Yi-Hsiang
Cheung, Ching-Lung
Dupuis, Josée
Saint-Pierre, Aude
Eriksson, Joel
Handelman, Samuel K.
Aragaki, Aaron K.
Karasik, David
Pramstaller, Peter P.
Kooperberg, Charles
Lacroix, Andrea Z.
Larson, Martin G.
Lau, Kam-Shing
Lorentzon, Mattias
Pichler, Irene
Sham, Pak Chung
Taliun, Daniel
Vandenput, Liesbeth
Kiel, Douglas P.
Hicks, Andrew A.
Jackson, Rebecca D.
Ohlsson, Claes
Benjamin, Emelia J.
Kung, Annie Wai Chee
Abstract
Osteoprotegerin (OPG) is involved in bone homeostasis and tumor cell survival. Circulating OPG levels are also important biomarkers of various clinical traits, such as cancers and atherosclerosis. OPG levels were measured in serum or in plasma. In a meta-analysis of genome-wide association studies in up to 10 336 individuals from European and Asian origin, we discovered that variants >100 kb upstream of the TNFRSF11B gene encoding OPG and another new locus on chromosome 17q11.2 were significantly associated with OPG variation. We also identified a suggestive locus on chromosome 14q21.2 associated with the trait. Moreover, we estimated that over half of the heritability of OPG levels could be explained by all variants examined in our study. Our findings provide further insight into the genetic regulation of circulating OPG levels.
Keywords
atherosclerosis, cancer, homeostasis, biological markers, cell survival, chromosomes, gene expression regulation, genes, plasma, single nucleotide polymorphism, neoplasmstumor necrosis factor receptor 11b, asian, genome-wide association study
Date
2014
Type
Journal article
Journal
Human Molecular Genetics
Book
Volume
23
Issue
24
Page Range
6684-6693
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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Source URL
Event URL
Open Access Status
License
File Access
Controlled