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PTHrP, its receptor, and protein kinase A activation in osteosarcoma
Walkley, Carl Walia, Mannu K. Ho, P.W.M. Martin, T. J.
Walkley, Carl
Walia, Mannu K.
Ho, P.W.M.
Martin, T. J.
Abstract
In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-dependent protein kinase A (PKA) and substantially decreases tumor differentiation, invasion, and proliferation in vivo. These findings complement other evidence supporting a central role of the PKA pathway in osteosarcoma biology and pathogenesis.
Keywords
Date
2014
Type
Journal article
Journal
Molecular & Cellular Oncology
Book
Volume
1
Issue
4
Page Range
1-3
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Open access
License
File Access
Open