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Augmented anabolic responses after 8-wk cycling with blood flow restriction
Conceição, Miguel Soares Mendes Telles, Guilherme Defante Libardi, Cleiton Augusto Castro, Alex Andrade, André L. L. Brum, Patrícia Chakur Urias, Úrsula Kurauti, Mirian Ayumi Costa
Conceição, Miguel Soares
Mendes
Telles, Guilherme Defante
Libardi, Cleiton Augusto
Castro, Alex
Andrade, André L. L.
Brum, Patrícia Chakur
Urias, Úrsula
Kurauti, Mirian Ayumi
Costa
Author
Conceição, Miguel Soares
Mendes
Telles, Guilherme Defante
Libardi, Cleiton Augusto
Castro, Alex
Andrade, André L. L.
Brum, Patrícia Chakur
Urias, Úrsula
Kurauti, Mirian Ayumi
Costa
Boschero, Antonio Carlos
Cavaglieri, Cláudia Regina
Camera, Donny M.
Chacon-Mikahil, Mara Patricia Traina
Junior, Edson Manoel Mendes
Júnior, José Maria Costa
Mendes
Telles, Guilherme Defante
Libardi, Cleiton Augusto
Castro, Alex
Andrade, André L. L.
Brum, Patrícia Chakur
Urias, Úrsula
Kurauti, Mirian Ayumi
Costa
Boschero, Antonio Carlos
Cavaglieri, Cláudia Regina
Camera, Donny M.
Chacon-Mikahil, Mara Patricia Traina
Junior, Edson Manoel Mendes
Júnior, José Maria Costa
Abstract
Introduction: Low-intensity endurance training (ET) performed with blood flow restriction (BFR) can improve muscle strength, cross-sectional area (CSA) and cardiorespiratory capacity.Whether muscle strength and CSA as well as cardiorespiratory capacity (i.e.,V˙ O2max) and underlying molecular processes regulating such respective muscle adaptations are comparable to resistance and ET is unknown. Purpose: To determine the respective chronic (i.e., 8 wk) functional, morphological, and molecular responses of ET-BFR training compared with conventional, unrestricted resistance training (RT) and ET. Methods: Thirty healthy young men were randomly assigned to one of three experimental groups: ET-BFR (n = 10, 4 dIwkj1, 30-min cycling at 40% of V˙ O2max), RT (n = 10, 4 dIwkj1, 4 sets of 10 repetitions leg press at 70% of one repetition maximum with 60 s rest) or ET (n = 10, 4 dIwkj1, 30-min cycling at 70%ofV˙ O2max) for 8 wk. Measures of quadriceps CSA, leg press one repetition maximum, and V˙ O2max as well as muscle biopsies were obtained before and after intervention. Results: Both RT and ET-BFR increased muscle strength and hypertrophy responses. ET-BFR also increased V˙ O2max, total cytochrome c oxidase subunit 4 isoform 1 abundance and vascular endothelial growth factor mRNA abundance despite the lower work load compared to ET. Conclusions: Eight weeks of ET-BFR can increase muscle strength and induce similar muscle hypertrophy responses to RT while V˙ O2max responses also increased postintervention even with a significantly lower work load compared with ET. Our findings provide new insight to some of the molecular mechanisms mediating adaptation responses with ET-BFR and the potential for this training protocol to improve muscle and cardiorespiratory capacity.
Keywords
vascular occlusion, muscle hypertrophy, cell signaling, angiogenesis, low-intensity exercise
Date
2019
Type
Journal article
Journal
Medicine and Science in Sports and Exercise
Book
Volume
51
Issue
1
Page Range
84-93
Article Number
ACU Department
Non-faculty
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled