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Air pollution and preterm premature rupture of membranes: A spatiotemporal analysis
Dadvand, Payam Basagaña, Xavier Figueras, Francesc Martínez, David Beelen, Rob Cirach, Marta de Nazelle, Audrey Hoek, Gerard Ostro, Bart Nieuwenhuijsen, Mark J.
Dadvand, Payam
Basagaña, Xavier
Figueras, Francesc
Martínez, David
Beelen, Rob
Cirach, Marta
de Nazelle, Audrey
Hoek, Gerard
Ostro, Bart
Nieuwenhuijsen, Mark J.
Abstract
Preterm premature rupture of membranes (PROM) is the leading identifiable predisposing factor for preterm birth. Although maternal exposure to air pollution can potentially have an impact on preterm PROM, there is no available evidence on such an impact. In this study, based on 5,555 singleton births occurring in Barcelona, Spain (2002–2005), we investigated the associations of maternal exposure to nitrogen dioxide, nitrogen oxides, and particulate matter with aerodynamic diameters of ≤2.5 µm (PM2.5), 2.5 µm–10 µm, and ≤10 µm and PM2.5 light absorption with preterm PROM and gestational age at the rupture of membranes (ROM). We utilized temporally adjusted land-use regression models to predict pollutant levels at each subject's home address during each week of her pregnancy. We conducted matched (according to the length of exposure) case-control analyses to estimate the preterm PROM risk associated with 1 interquartile-range increase in exposure levels during the entire pregnancy and during the last 3 months prior to ROM. We found an increase in preterm PROM risk of up to 50% (95% confidence interval: 4, 116) and a 1.3-day (95% confidence interval: −1.9, −0.6) reduction in gestational age at ROM associated with PM2.5 absorbance, nitrogen dioxide exposure, and nitrogen oxide exposure during the entire pregnancy and the last 3 months prior to ROM.
Keywords
air pollution, land-use regression, maternal exposure, nitrogen oxides, particulate matter, pregnancy, premature rupture of membranes, preterm birth
Date
2014
Type
Journal article
Journal
American Journal of Epidemiology
Book
Volume
179
Issue
2
Page Range
200-207
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled