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Live high, train low – influence on resting and post-exercise hepcidin levels
Govus, Andrew D. Peeling, P. Abbiss, C R. Lawler, N. G. Swinkels, D. W. Laarakkers, C. M. Thompson, K. G. Peiffer, J. J. Gore, C. J. Garvican-Lewis, L. A.
Govus, Andrew D.
Peeling, P.
Abbiss, C R.
Lawler, N. G.
Swinkels, D. W.
Laarakkers, C. M.
Thompson, K. G.
Peiffer, J. J.
Gore, C. J.
Garvican-Lewis, L. A.
Abstract
The post‐exercise hepcidin response during prolonged ( > 2 weeks) hypoxic exposure is not well understood. We compared plasma hepcidin levels 3 h after exercise [6 × 1000 m at 90% of maximal aerobic running velocity (vVO2max)] performed in normoxia and normobaric hypoxia (3000 m simulate altitude) 1 week before, and during 14 days of normobaric hypoxia [196.2 ± 25.6 h (median: 200.8 h; range: 154.3–234.8 h) at 3000 m simulated altitude] in 10 well‐trained distance runners (six males, four females). Venous blood was also analyzed for hepcidin after 2 days of normobaric hypoxia. Hemoglobin mass (Hbmass) was measured via CO rebreathing 1 week before and after 14 days of hypoxia. Hepcidin was suppressed after 2 (Cohen's d = −2.3, 95% confidence interval: [−2.9, −1.6]) and 14 days of normobaric hypoxia (d = −1.6 [−2.6, −0.6]). Hepcidin increased from baseline, 3 h post‐exercise in normoxia (d = 0.8 [0.2, 1.3]) and hypoxia (d = 0.6 [0.3, 1.0]), both before and after exposure (normoxia: d = 0.7 [0.3, 1.2]; hypoxia: d = 1.3 [0.4, 2.3]). In conclusion, 2 weeks of normobaric hypoxia suppressed resting hepcidin levels, but did not alter the post‐exercise response in either normoxia or hypoxia, compared with the pre‐exposure response.
Keywords
iron metabolism, iron deficiency, altitude training, hypoxia
Date
2017
Type
Journal article
Journal
Scandinavian Journal of Medicine & Science in Sports
Book
Volume
27
Issue
7
Page Range
704-713
Article Number
ACU Department
Centre for Exercise and Nutrition
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled