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Serum 25-Hydroxyvitamin D is associated with cognitive executive function in dutch prefrail and frail elderly: A cross-sectional study exploring the associations of 25-hydroxyvitamin D with glucose metabolism, cognitive performance and depression
Brouwer-Brolsma, Elske M. Van De Rest, Ondine Tieland, Michael Van Der Zwalu, Nikita L. Steegenga, Wilma T. Adam, Jos J. Van Loon, Luc J.C. Feskens, Edith J.M. de Groot, Lisette C. P. G. M.
Brouwer-Brolsma, Elske M.
Van De Rest, Ondine
Tieland, Michael
Van Der Zwalu, Nikita L.
Steegenga, Wilma T.
Adam, Jos J.
Van Loon, Luc J.C.
Feskens, Edith J.M.
de Groot, Lisette C. P. G. M.
Abstract
Objectives: The primary objective was to explore the possible association of serum 25-hydroxyvitamin D (25[OH]D) and vitamin D intake with markers of glucose metabolism, depression, and cognitive performance. In addition, we examined to what extent the associations between vitamin D and cognitive performance were modified or mediated by fasting plasma glucose (FPG) levels. Design, Setting, and Participants: Cross-sectional study using data of 127 frail or prefrail Dutch elderly, aged 65 years or older. Frailty was defined according to the criteria of Fried and colleagues. A participant was classified prefrail when 1 to 2 criteria were met; frailty was classified as the presence of 3 or more criteria. Measurements: Associations of 25(OH)D and vitamin D intake with markers of glucose metabolism and domain-specific cognitive performance were examined by multivariable regression analyses. The possible association of vitamin D with depression and global cognitive performance was explored by Poisson regression. Results: No associations were observed for 25(OH)D with FPG, fasting plasma insulin (FPI), Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR), or depression. In contrast, serum 25(OH)D was positively associated with executive functioning (b 0.007, P ¼ .01) and tended to be associated with information-processing speed (b 0.006, P ¼ .06). FPG did not modify or mediate these associations. Vitamin D intake was not associated with cognitive performance, glucose metabolism, or depression. Conclusion: This cross-sectional study suggests an association of serum 25(OH)D with domain-specific cognitive performance, in particular executive functioning and possibly information-processing speed, but not with FPG, FPI, HOMA-IR, or depression. Whether these associations are causal is yet to be demonstrated.
Keywords
Vitamin D, glucose metabolism, cognition, depression, aging, cross-sectional
Date
2013
Type
Journal article
Journal
Journal of the American Medical Directors Association
Book
Volume
14
Issue
11
Page Range
9-17
Article Number
ACU Department
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Source URL
Event URL
Open Access Status
License
File Access
Controlled