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Low 25-OH vitamin d is associated with benign prostatic hyperplasia
Haghsheno, Mohammad-Ali Mellström, Dan Behre, Carl-Johan Damber, Jan-Erik Johansson, Helena Karlsson, Magnus Lorentzon, Mattias Peeker, Ralph Barret-Connor, Elisabet Waern, Ewa
Haghsheno, Mohammad-Ali
Mellström, Dan
Behre, Carl-Johan
Damber, Jan-Erik
Johansson, Helena
Karlsson, Magnus
Lorentzon, Mattias
Peeker, Ralph
Barret-Connor, Elisabet
Waern, Ewa
Abstract
Purpose:
We tested the hypothesis that low vitamin D is associated with benign prostatic hyperplasia. We also studied whether body composition, sex hormones, serum sex hormone-binding globulin, albumin corrected serum calcium, adiponectin and lipid status are associated with benign prostatic hyperplasia.
Materials and Methods:
We investigated 184 representative, randomly selected men 72 to 76 years old enrolled in the Gothenburg arm of the Osteoporotic Fractures in Men Study (MrOS). Men with a history of prostate cancer, prostate operation or medication for benign prostatic hyperplasia were excluded from study, leaving 155 available for analysis. A cross-sectional study was performed in which benign prostatic hyperplasia measured by total prostate volume was related to clinical, anthropometric, endocrine and metabolic factors on univariate and multivariate analyses with regression models.
Results:
Median prostate volume was 40 ml. In multivariate models only 25-OH vitamin D, albumin corrected serum calcium, serum sex hormone-binding globulin and high density lipoprotein cholesterol were significantly and inversely associated with large prostate glands.
Conclusions:
The current report adds 4 independent factors associated with benign prostatic hyperplasia, including low 25-OH vitamin D, serum calcium, sex hormone-binding globulin and high density lipoprotein cholesterol.
Keywords
prostate, prostatic hyperplasia, sex hormone-binding globulin, lipoproteins, HDL, vitamin D
Date
2013
Type
Journal article
Journal
Book
Volume
190
Issue
2
Page Range
608-614
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled