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Acute Heart Failure and Atrial Fibrillation: Insights From the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF) Trial
Abualnaja, Seraj Podder, Mohua Hernandez, Adrian F. McMurray, John J.V. Starling, Randall C. O'Connor, Christopher M. Califf, Robert M. Armstrong, Paul W. Ezekowitz, Justin A.
Abualnaja, Seraj
Podder, Mohua
Hernandez, Adrian F.
McMurray, John J.V.
Starling, Randall C.
O'Connor, Christopher M.
Califf, Robert M.
Armstrong, Paul W.
Ezekowitz, Justin A.
Abstract
Background-—Patients with acute heart failure (AHF) frequently have atrial fibrillation (AF), but how this affects patient-reported outcomes has not been well characterized. Methods and Results-—We examined dyspnea improvement and clinical outcomes in 7007 patients in the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF) trial. At baseline, 2677 (38.2%) patients had current or a history of AF and 4330 (61.8%) did not. Patients with a history of AF were older than those without (72 vs. 63 years) and had more comorbidities and a higher median left ventricular ejection fraction (31% vs. 27%, P
Keywords
acute heart failure, atrial fibrillation, clinical trials, outcome
Date
2015
Type
Journal article
Journal
Journal of the American Heart Association
Book
Volume
4
Issue
8
Page Range
1-8
Article Number
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
File Access
Controlled
Notes
© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.