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Specialization of amygdala subregions in emotion processing
Labuschagne, Izelle Dominguez, Juan F. Sally, Grace Mizzi, Simone Henry, Julie D. Peters, Craig Rabinak, Christine A. Sinclair, Erin Lorenzetti, Valentina Terrett, Gill
Labuschagne, Izelle
Dominguez, Juan F.
Sally, Grace
Mizzi, Simone
Henry, Julie D.
Peters, Craig
Rabinak, Christine A.
Sinclair, Erin
Lorenzetti, Valentina
Terrett, Gill
Abstract
The amygdala is important for human fear processing. However, recent research has failed to reveal specificity, with evidence that the amygdala also responds to other emotions. A more nuanced understanding of the amygdala's role in emotion processing, particularly relating to fear, is needed given the importance of effective emotional functioning for everyday function and mental health. We studied 86 healthy participants (44 females), aged 18–49 (mean 26.12 ± 6.6) years, who underwent multiband functional magnetic resonance imaging. We specifically examined the reactivity of four amygdala subregions (using regions of interest analysis) and related brain connectivity networks (using generalized psycho-physiological interaction) to fear, angry, and happy facial stimuli using an emotional face-matching task. All amygdala subregions responded to all stimuli (p-FDR < .05), with this reactivity strongly driven by the superficial and centromedial amygdala (p-FDR < .001). Yet amygdala subregions selectively showed strong functional connectivity with other occipitotemporal and inferior frontal brain regions with particular sensitivity to fear recognition and strongly driven by the basolateral amygdala (p-FDR < .05). These findings suggest that amygdala specialization to fear may not be reflected in its local activity but in its connectivity with other brain regions within a specific face-processing network.
Keywords
centromedial, facial expressions, fear, fMRI, superficial
Date
2024
Type
Journal article
Journal
Human Brain Mapping
Book
Volume
45
Issue
5
Page Range
1-11
Article Number
Article e26673
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open
Notes
© 2024 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.