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Interrupting sitting time in postmenopausal women : Protocol for the rise for health randomized controlled trial
Hartman, Sheri J. Dillon, Lindsay W. LaCroix, Andrea Z. Natarajan, Loki Sears, Dorothy D. Owen, Neville Dunstan, David W. Sallis, James F. Schenk, Simon Allison, Matthew
Hartman, Sheri J.
Dillon, Lindsay W.
LaCroix, Andrea Z.
Natarajan, Loki
Sears, Dorothy D.
Owen, Neville
Dunstan, David W.
Sallis, James F.
Schenk, Simon
Allison, Matthew
Abstract
Background:
Many older adults spend the majority of their waking hours sitting, which increases their risk of chronic diseases. Given the challenges that many older adults face when engaging in moderate-to-vigorous physical activity, understanding the health benefits of decreasing sitting time and increasing the number of sit-to-stand transitions is needed to address this growing public health concern.
Objective:
The aim of this 3-arm randomized controlled trial is to investigate how changes in sitting time and brief sit-to-stand transitions impact biomarkers of healthy aging and physical, emotional, and cognitive functioning compared with a healthy attention control arm.
Methods:
Sedentary and postmenopausal women (N=405) will be recruited and randomly assigned to 1 of the 3 study conditions for 3 months: healthy living attention control (Healthy Living), reduce sitting time (Reduce Sitting), and increase sit-to-stand transitions (Increase Transitions). Assessments conducted at baseline and 3 months included fasting blood draw, blood pressure, anthropometric measurements, physical functioning, cognitive testing, and 7 days of a thigh-worn accelerometer (activPAL) and a hip-worn accelerometer (ActiGraph). Blood-based biomarkers of healthy aging included those associated with glycemic control (glycated hemoglobin, fasting plasma insulin and glucose, and homeostatic model assessment of insulin resistance).
Results:
Recruitment began in May 2018. The intervention is ongoing, with data collection expected to continue through the end of 2022.
Conclusions:
The Rise for Health study is designed to test whether 2 different approaches to interrupting sitting time can improve healthy aging in postmenopausal women. Results from this study may inform the development of sedentary behavior guidelines and interventions to reduce sitting time in older adults.
Trial Registration:
ClinicalTrials.gov NCT03473145; https://clinicaltrials.gov/ct2/show/NCT03473145
International Registered Report Identifier (IRRID):
DERR1-10.2196/28684
Keywords
sedentary behavior, cardiometabolic health, older adults, physical function, cognitive function, biomarkers
Date
2021
Type
Journal article
Journal
JMIR Research Protocols
Book
Volume
10
Issue
5
Page Range
1-17
Article Number
Article e28684
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
DOI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open