Loading...
Different frequencies of active interruptions to sitting have distinct effects on 22 h glycemic control in type 2 diabetes
Homer, Ashleigh R. Taylor, Frances C. Dempsey, Paddy C. Wheeler, Michael J. Sethi, Parneet Grace, Megan S. Green, Daniel J. Cohen, Neale D. Larsen, Robyn N. Kingwell, Bronwyn A.
Homer, Ashleigh R.
Taylor, Frances C.
Dempsey, Paddy C.
Wheeler, Michael J.
Sethi, Parneet
Grace, Megan S.
Green, Daniel J.
Cohen, Neale D.
Larsen, Robyn N.
Kingwell, Bronwyn A.
Abstract
Background & aims
Whether the frequency of interruptions to sitting time involving simple resistance activities (SRAs), compared to uninterrupted sitting, differentially affected 22 h glycemic control in adults with medication-controlled type 2 diabetes (T2D).
Methods & results
Twenty-four participants (13 men; mean ± SD age 62 ± 8 years) completed three 8 h laboratory conditions: SIT: uninterrupted sitting; SRA3: sitting interrupted with 3 min of SRAs every 30 min; and, SRA6: sitting interrupted with 6 min of SRAs every 60 min. Flash glucose monitors assessed glycemic control over a 22 h period. No differences were observed between conditions for overall 22 h glycemic control as measured by AUCtotal, mean glucose and time in hyperglycemia. During the 3.5 h post-lunch period, mean glucose was significantly lower during SRA6 (10.1 mmol·L−1, 95%CI 9.2, 11.0) compared to SIT (11.1 mmol·L−1, 95%CI 10.2, 12.0; P = 0.006). Post-lunch iAUCnet was significantly lower during SRA6 (6.2 mmol·h·L−1, 95%CI 3.3, 9.1) compared to SIT (9.9 mmol·h·L−1, 95%CI 7.0, 12.9; P = 0.003). During the post-lunch period, compared to SIT (2.2 h, 95%CI 1.7, 2.6), time in hyperglycemia was significantly lower during SRA6 (1.5 h, 95%CI 1.0, 1.9, P = 0.001). Nocturnal mean glucose was significantly lower following the SRA3 condition (7.6 mmol·L−1, 95%CI 7.1, 8.1) compared to SIT (8.1 mmol·L−1, 95%CI 7.6, 8.7, P = 0.024).
Conclusions
With standardized total activity time, less-frequent active interruptions to sitting may acutely improve glycemic control; while more-frequent interruptions may be beneficial for nocturnal glucose in those with medication-controlled T2D.
Keywords
type 2 diabetes, sedentary behaviour, glycemic control, postprandial glucose, nocturnal glucose, active breaks
Date
2021
Type
Journal article
Journal
Nutrition Metabolism and Cardiovascular Diseases
Book
Volume
31
Issue
10
Page Range
2969-2978
Article Number
ACU Department
Centre for Exercise and Nutrition
Faculty of Health Sciences
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Mary MacKillop Institute for Health Research
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled