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Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance?
Carmichael, Lauren Keske, Michelle A. Betik, Andrew C. Parker, Lewan Brayner, Barbara Roberts-Thomson, Katherine M. Wadley, Glen D. Hamilton, D. Lee Kaur, Gunveen
Carmichael, Lauren
Keske, Michelle A.
Betik, Andrew C.
Parker, Lewan
Brayner, Barbara
Roberts-Thomson, Katherine M.
Wadley, Glen D.
Hamilton, D. Lee
Kaur, Gunveen
Abstract
There is increasing evidence that skeletal muscle microvascular (capillary) blood flow plays an important role in glucose metabolism by increasing the delivery of glucose and insulin to the myocytes. This process is impaired in insulin-resistant individuals. Studies suggest that in diet-induced insulin-resistant rodents, insulin-mediated skeletal muscle microvascular blood flow is impaired post-short-term high fat feeding, and this occurs before the development of myocyte or whole-body insulin resistance. These data suggest that impaired skeletal muscle microvascular blood flow is an early vascular step before the onset of insulin resistance. However, evidence of this is still lacking in humans. In this review, we summarise what is known about short-term high-calorie and/or high-fat feeding in humans. We also explore selected animal studies to identify potential mechanisms. We discuss future directions aimed at better understanding the ‘early’ vascular mechanisms that lead to insulin resistance as this will provide the opportunity for much earlier screening and timing of intervention to assist in preventing type 2 diabetes.
Keywords
Date
2022
Type
Journal article
Journal
Nutrition and Diabetes
Book
Volume
12
Issue
1
Page Range
1-12
Article Number
Article 31
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open
Notes
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