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Different frequency of Heschl’s gyrus duplication patterns in neuropsychiatric disorders : An MRI study in bipolar and major depressive disorders
Takahashi, Tsutomu Sasabayashi, Daiki Yücel, Murat Whittle, Sarah Lorenzetti, Valentina Walterfang, Mark Suzuki, Michio Pantelis, Christos Malhi, Gin S. Allen, Nicholas B.
Takahashi, Tsutomu
Sasabayashi, Daiki
Yücel, Murat
Whittle, Sarah
Lorenzetti, Valentina
Walterfang, Mark
Suzuki, Michio
Pantelis, Christos
Malhi, Gin S.
Allen, Nicholas B.
Abstract
An increased prevalence of duplicated Heschl’s gyrus (HG) has been repeatedly demonstrated in various stages of schizophrenia as a potential neurodevelopmental marker, but it remains unknown whether other neuropsychiatric disorders also exhibit this macroscopic brain feature. The present magnetic resonance imaging study aimed to examine the disease specificity of the established finding of altered HG patterns in schizophrenia by examining independent cohorts of bipolar disorder (BD) and major depressive disorder (MDD). Twenty-six BD patients had a significantly higher prevalence of HG duplication bilaterally compared to 24 age- and sex-matched controls, while their clinical characteristics (e.g., onset age, number of episodes, and medication) did not relate to HG patterns. No significant difference was found for the HG patterns between 56 MDD patients and 33 age- and sex-matched controls, but the patients with a single HG were characterized by more severe depressive/anxiety symptoms compared to those with a duplicated HG. Thus, in keeping with previous findings, the present study suggests that neurodevelopmental pathology associated with gyral formation of the HG during the late gestation period partly overlaps between schizophrenia and BD, but that HG patterns may make a somewhat distinct contribution to the phenomenology of MDD.
Keywords
superior temporal gyrus, Heschl’s gyrus, gyrification, major depressive disorder, bipolar disorder
Date
2022
Type
Journal article
Journal
Frontiers in Human Neuroscience
Book
Volume
16
Issue
Page Range
1-10
Article Number
Article 917270
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open