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New genetic loci link adipose and insulin biology to body fat distribution
Shungin, Dmitry Winkler, Thomas W. Croteau-Chonka, Damien C. Ferreira, Teresa Locke, Adam E. Mägi, Reedik Strawbridge, Rona J. Pers, Tune H. Fischer, Krista Justice, Anne E.
Shungin, Dmitry
Winkler, Thomas W.
Croteau-Chonka, Damien C.
Ferreira, Teresa
Locke, Adam E.
Mägi, Reedik
Strawbridge, Rona J.
Pers, Tune H.
Fischer, Krista
Justice, Anne E.
Author
Shungin, Dmitry
Winkler, Thomas W.
Croteau-Chonka, Damien C.
Ferreira, Teresa
Locke, Adam E.
Mägi, Reedik
Strawbridge, Rona J.
Pers, Tune H.
Fischer, Krista
Justice, Anne E.
Workalemahu, Tsegaselassie
Wu, Joseph M. W.
Buchkovich, Martin L.
Heard-Costa, Nancy L.
Roman, Tamara S.
Drong, Alexander W.
Song, Ci
Gustafsson, Stefan
Day, Felix R.
Esko, Tonu
Fall, Tove
Kutalik, Zoltán
Luan, Jian'an
Randall, Joshua C.
Scherag, André
Vedantam, Sailaja
Wood, Andrew R.
Chen, Jin
Fehrmann, Rudolf
Lorentzon, Mattias
Winkler, Thomas W.
Croteau-Chonka, Damien C.
Ferreira, Teresa
Locke, Adam E.
Mägi, Reedik
Strawbridge, Rona J.
Pers, Tune H.
Fischer, Krista
Justice, Anne E.
Workalemahu, Tsegaselassie
Wu, Joseph M. W.
Buchkovich, Martin L.
Heard-Costa, Nancy L.
Roman, Tamara S.
Drong, Alexander W.
Song, Ci
Gustafsson, Stefan
Day, Felix R.
Esko, Tonu
Fall, Tove
Kutalik, Zoltán
Luan, Jian'an
Randall, Joshua C.
Scherag, André
Vedantam, Sailaja
Wood, Andrew R.
Chen, Jin
Fehrmann, Rudolf
Lorentzon, Mattias
Abstract
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10−8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
Keywords
Date
2015
Type
Journal article
Journal
Nature
Book
Volume
518
Issue
Page Range
187-196
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled
Notes
Please refer to the journal article webpage for a complete list of author names.