Carbohydrate co-ingestion with protein does not further augment post-prandial muscle protein accretion in older men

Journal article


Hamer, Henrike M., Wall, Benjamin T., Kiskini, Alexandra, de Lange, Anneke, Groen, Bart B. L., Bakker, Jaap A., Gijsen, Annemie P., Verdijk, Lex B. and van Loon, Luc J. C. 2013. Carbohydrate co-ingestion with protein does not further augment post-prandial muscle protein accretion in older men. Nutrition and Metabolism. 10 (1), pp. 1 - 9. https://doi.org/10.1186/1743-7075-10-15
AuthorsHamer, Henrike M., Wall, Benjamin T., Kiskini, Alexandra, de Lange, Anneke, Groen, Bart B. L., Bakker, Jaap A., Gijsen, Annemie P., Verdijk, Lex B. and van Loon, Luc J. C.
Abstract

Background: A blunted muscle protein synthetic response to protein ingestion may contribute to the age related loss of muscle tissue. We hypothesized that the greater endogenous insulin release following co-ingestion of carbohydrate facilitates post-prandial muscle protein accretion after ingesting a meal-like bolus of protein in older males. Methods: Twenty-four healthy older men ( 75±1 y ) were randomly assigned to ingest 20 g intrinsically L-[1-13C] phenylalanine-labeled casein protein with ( PRO-CHO ) or without ( PRO ) 40 g carbohydrate. Ingestion of specifically produced intrinsically L-[1-13C] phenylalanine labeled protein allowed us to assess post-prandial incorporation of dietary protein derived amino acids into muscle protein. Blood samples were collected at regular intervals, with muscle biopsies being obtained prior to and 2 and 6 h after protein ingestion. Results: Plasma glucose and insulin concentrations showed a greater increase in PRO-CHO compared with PRO ( P < 0.001 ). Muscle protein-bound L-[1-13C] phenylalanine enrichments tended to increase to a greater extent in PRO-CHO compared with PRO during the first 2 h after protein ingestion ( 0.0072±0.0013 vs 0.0046±0.010 MPE, respectively; P=0.13 ). However, 6 h after protein ingestion, differences in muscle protein-bound L-[1-13C] phenylalanine enrichments were no longer observed between experiments ( 0.0213±0.0024 vs 0.0185±0.0010 MPE, respectively; P=0.30 ). Conclusions: This study shows that carbohydrate ingestion may accelerate, but does not further augment post-prandial incorporation of dietary protein derived amino acids into muscle protein in healthy elderly men.

Keywordsskeletal muscle; ageing; sarcopenia; amino acids; anabolic resistance
Year2013
JournalNutrition and Metabolism
Journal citation10 (1), pp. 1 - 9
PublisherBiomed Central Ltd
ISSN1743-7075
Digital Object Identifier (DOI)https://doi.org/10.1186/1743-7075-10-15
Scopus EID2-s2.0-84872825886
Open accessOpen access
Page range1 - 9
Research GroupMary MacKillop Institute for Health Research
Publisher's version
Additional information

© 2013 Hamer et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Place of publicationUnited Kingdom
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