Latent profile analysis and conversion to psychosis: Characterizing subgroups to enhance risk prediction

Journal article


Healey, Kristin M., Penn, David L., Perkins, Diana, Woods, Scott W., Keefe, Richard S. E. and Addington, Jean. (2018). Latent profile analysis and conversion to psychosis: Characterizing subgroups to enhance risk prediction. Schizophrenia Bulletin. 44(2), pp. 286 - 296. https://doi.org/10.1093/schbul/sbx080
AuthorsHealey, Kristin M., Penn, David L., Perkins, Diana, Woods, Scott W., Keefe, Richard S. E. and Addington, Jean
Abstract

Background: Groups at clinical high risk (CHR) of developing psychosis are heterogeneous, composed of individuals with different clusters of symptoms. It is likely that there exist subgroups, each associated with different symptom constellations and probabilities of conversion. Method: Present study used latent profile analysis (LPA) to ascertain subgroups in a combined sample of CHR (n = 171) and help-seeking controls (HSCs; n = 100; PREDICT study). Indicators in the LPA model included baseline Scale of Prodromal Symptoms (SOPS), Calgary Depression Scale for Schizophrenia (CDSS), and neurocognitive performance as measured by multiple instruments, including category instances (CAT). Subgroups were further characterized using covariates measuring demographic and clinical features. Results: Three classes emerged: class 1 (mild, transition rate 5.6%), lowest SOPS and depression scores, intact neurocognitive performance; class 2 (paranoid-affective, transition rate 14.2%), highest suspiciousness, mild negative symptoms, moderate depression; and class 3 (negative-neurocognitive, transition rate 29.3%), highest negative symptoms, neurocognitive impairment, social cognitive impairment. Classes 2 and 3 evidenced poor social functioning. Conclusions: Results support a subgroup approach to research, assessment, and treatment of help-seeking individuals. Class 3 may be an early risk stage of developing schizophrenia.

Keywordsclinical high risk; ultra high risk; neurocognition; psychosis; functioning; early intervention; negative symptoms
Year2018
JournalSchizophrenia Bulletin
Journal citation44 (2), pp. 286 - 296
PublisherOxford University Press
ISSN0586-7614
Digital Object Identifier (DOI)https://doi.org/10.1093/schbul/sbx080
Scopus EID2-s2.0-85048967997
Page range286 - 296
Publisher's version
File Access Level
Controlled
Place of publicationUnited Kingdom
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