Compression socks and the effects on coagulation and fibrinolytic activation during marathon running

Journal article


Zadow, E. K., Adams, M. J., Wu, S. S. X., Kitic, C. M., Singh, I., Kundur, A., Bost, Nerolie, Johnston, A. N. B., Crilly, Julia, Bulmer, A. C., Halson, Shona L. and Fell, James W.. (2018). Compression socks and the effects on coagulation and fibrinolytic activation during marathon running. European Journal of Applied Physiology. 118(10), pp. 2171 - 2177. https://doi.org/10.1007/s00421-018-3929-5
AuthorsZadow, E. K., Adams, M. J., Wu, S. S. X., Kitic, C. M., Singh, I., Kundur, A., Bost, Nerolie, Johnston, A. N. B., Crilly, Julia, Bulmer, A. C., Halson, Shona L. and Fell, James W.
Abstract

Purpose Compression socks are frequently used in the treatment and prevention of lower-limb pathologies; however, when combined with endurance-based exercise, the impact of compression socks on haemostatic activation remains unclear. Objectives To investigate the effect of wearing compression socks on coagulation and fibrinolysis following a marathon. Methods Sixty-seven participants [43 males (mean ± SD: age: 46.7 ± 10.3 year) and 24 females (age: 40.0 ± 11.0 year)] were allocated into a compression (SOCK, n = 34) or control (CONTROL, n = 33) group. Venous blood samples were obtained 24 h prior to and immediately POST-marathon, and were analyzed for thrombin–anti-thrombin complex (TAT), tissue factor (TF), tissue factor pathway inhibitor (TFPI), and D-Dimer. Results Compression significantly attenuated the post-exercise increase in D-Dimer compared to the control group [median (range) SOCK: + 9.02 (− 0.34 to 60.7) ng/mL, CONTROL: + 25.48 (0.95–73.24) ng/mL]. TF increased following the marathon run [median (range), SOCK: + 1.19 (− 7.47 to 9.11) pg/mL, CONTROL: + 3.47 (− 5.01 to 38.56) pg/mL] in all runners. No significant post-exercise changes were observed for TAT and TFPI. Conclusions While activation of coagulation and fibrinolysis was apparent in all runners POST-marathon, wearing compression socks was shown to reduce fibrinolytic activity, as demonstrated by lower D-Dimer concentrations. Compression may reduce exercise-associated haemostatic activation when completing prolonged exercise.

Keywordscompression; D-dimer; tissue factor; tissue factor pathway inhibitor; thrombin–anti-thrombin complexes
Year2018
JournalEuropean Journal of Applied Physiology
Journal citation118 (10), pp. 2171 - 2177
PublisherSpringer
ISSN1439-6319
Digital Object Identifier (DOI)https://doi.org/10.1007/s00421-018-3929-5
Scopus EID2-s2.0-85050645634
Page range2171 - 2177
Research GroupSports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre
Publisher's version
File Access Level
Controlled
Place of publicationGermany
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