Origin of cardiac Troponin T Elevations in chronic kidney disease

Journal article

van der Linden, Noreen, Cornelis, Tom, Kimenai, Dorien M., Klinkenberg, Lieke J. J., Hilderink, Judith M., Lück, Sarah, Litjens, Elisabeth J. R., Peeters, Frederique E. C. M., Streng, Alexander S., Breidthardt, Tobias, van Loon, Luc J. C., Bekers, Otto, Kooman, Jeroen P., Westermark, Pål O., Mueller, Christian and Meex, Steven J. R.. (2017). Origin of cardiac Troponin T Elevations in chronic kidney disease. Circulation. 136(11), pp. 1073 - 1075. https://doi.org/10.1161/CIRCULATIONAHA.117.029986
Authorsvan der Linden, Noreen, Cornelis, Tom, Kimenai, Dorien M., Klinkenberg, Lieke J. J., Hilderink, Judith M., Lück, Sarah, Litjens, Elisabeth J. R., Peeters, Frederique E. C. M., Streng, Alexander S., Breidthardt, Tobias, van Loon, Luc J. C., Bekers, Otto, Kooman, Jeroen P., Westermark, Pål O., Mueller, Christian and Meex, Steven J. R.
Abstract

[Extract] Plasma concentrations of cardiac troponins, the preferred biomarkers for the diagnosis of acute myocardial infarction, are often persistently elevated in patients with chronic kidney disease (CKD). The origin of these elevations is unknown: Is it the heart, by increased release, or the kidneys, by decreased renal elimination? In clinical practice, this equivocal view on troponin elevations in patients with reduced glomerular clearance underlies countless clinical discussions among physicians and may delay rapid initiation of adequate treatment when these patients present with chest pain.

Keywordskidney diseases; troponin
Year2017
JournalCirculation
Journal citation136 (11), pp. 1073 - 1075
PublisherLippincott Williams & Wilkins
ISSN0009-7322
Digital Object Identifier (DOI)https://doi.org/10.1161/CIRCULATIONAHA.117.029986
Page range1073 - 1075
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Place of publicationUnited States of America
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