The course of uveitis in pregnancy and postpartum

Journal article

Chiam, Nathalie P. Y., Hall, Anthony J. H., Stawell, Richard J., Busija, Lucy and Lim, Lyndell L. P.. (2013). The course of uveitis in pregnancy and postpartum. British Journal of Ophthalmology. 97(10), pp. 1284 - 1288.
AuthorsChiam, Nathalie P. Y., Hall, Anthony J. H., Stawell, Richard J., Busija, Lucy and Lim, Lyndell L. P.

Aim To examine the course of non-infectious uveitis during pregnancy. Methods This is a retrospective case series. The medical records of 47 subjects with a previous history of non-infectious uveitis pre-dating their pregnancy were reviewed. Uveitis activity during the periods 1 year before pregnancy, during pregnancy and 1 year postpartum, were recorded. Information on patient demographics, type of uveitis, medication use, sex of child and breastfeeding status were also collected. The main outcome measures were the events of flare-ups during the prepregnancy, pregnancy and postpartum periods. Results The rate of flare-up was 1.188 per person year prior to pregnancy, 0.540 per person year during pregnancy and 0.972 per person year in postpartum (p < 0.001 for comparison between prepregnancy and pregnancy; p=0.009 for comparison between pregnancy and postpartum). Rates of flare-up only began to decrease in the second trimester. After delivery, rates of flare-up rebounded and within 6 months postpartum, flare-up rates were not significantly different from prepregnancy levels (p=0.306). Even so, 40% of subjects were found to have remained inactive within 1 year postpartum. Conclusions Uveitis activity decreased by mid-pregnancy, but returned to prepregnancy levels within 6 months postpartum. These findings may be used to adjust uveitis management during pregnancy and the postpartum period.

JournalBritish Journal of Ophthalmology
Journal citation97 (10), pp. 1284 - 1288
Digital Object Identifier (DOI)
Page range1284 - 1288
Research GroupInstitute for Health and Ageing
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