The effect of exercise training on the course of cardiac troponin T and i levels: Three independent training studies

Journal article


van der Linden, Noreen, Klinkenberg, Lieke J. J., Leenders, Marika, Tieland, Michael, Verdijk, Lex B., Niens, Marijke, van Suijlen, Jeroen D. E., de Groot, Lisette C. P. G. M., Bekers, Otto, van Loon, Luc J. C., van Dieijen-Visser, Marja P. and Meex, Steven J. R.. (2015) The effect of exercise training on the course of cardiac troponin T and i levels: Three independent training studies. Scientific Reports. 5, pp. 1 - 6. https://doi.org/10.1038/srep18320
Authorsvan der Linden, Noreen, Klinkenberg, Lieke J. J., Leenders, Marika, Tieland, Michael, Verdijk, Lex B., Niens, Marijke, van Suijlen, Jeroen D. E., de Groot, Lisette C. P. G. M., Bekers, Otto, van Loon, Luc J. C., van Dieijen-Visser, Marja P. and Meex, Steven J. R.
Abstract

With the introduction of high-sensitive assays, cardiac troponins became potential biomarkers for risk stratification and prognostic medicine. Observational studies have reported an inverse association between physical activity and basal cardiac troponin levels. However, causality has never been demonstrated. This study investigated whether basal cardiac troponin concentrations are receptive to lifestyle interventions such as exercise training. Basal high-sensitive cardiac troponin T ( cTnT ) and I ( cTnI ) were monitored in two resistance-type exercise training programs ( 12-week ( study 1 ) and 24-week ( study 2 ) ) in older adults ( ≥65 years ). In addition, a retrospective analysis for high sensitive troponin I in a 24-week exercise controlled trial in ( pre )frail older adults was performed ( study 3 ). In total, 91 subjects were included in the final data analyses. There were no significant changes in cardiac troponin levels over time in study 1 and 2 ( study 1: cTnT −0.13 ( −0.33–+0.08 ) ng/L/12-weeks, cTnI −0.10 ( −0.33–+0.12 ) ng/L/12-weeks; study 2: cTnT −1.99 ( −4.79–+0.81 ) ng/L/24-weeks, cTnI −1.59 ( −5.70–+2.51 ) ng/L/24-weeks ). Neither was there a significant interaction between training and the course of cardiac troponin in study 3 ( p = 0.27 ). In conclusion, this study provides no evidence that prolonged resistance-type exercise training can modulate basal cardiac troponin levels.

Year2015
JournalScientific Reports
Journal citation5, pp. 1 - 6
PublisherNature Publishing Group
ISSN2045-2322
Digital Object Identifier (DOI)https://doi.org/10.1038/srep18320
Scopus EID2-s2.0-84950269838
Open accessOpen access
Page range1 - 6
Research GroupMary MacKillop Institute for Health Research
Publisher's version
Additional information

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Place of publicationUnited Kingdom
Permalink -

https://acuresearchbank.acu.edu.au/item/88z81/the-effect-of-exercise-training-on-the-course-of-cardiac-troponin-t-and-i-levels-three-independent-training-studies

  • 5
    total views
  • 7
    total downloads
  • 0
    views this month
  • 1
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as