Muscle fibre capillarization is a critical factor in muscle fibre hypertrophy during resistance exercise training in older men

Journal article


Snijders, Tim, Nederveen, Joshua P., Joanisse, Sophie, Leenders, Marika, Verdijk, Lex B., Van Loon, Luc J. C. and Parise, Gianni 2016. Muscle fibre capillarization is a critical factor in muscle fibre hypertrophy during resistance exercise training in older men. Journal of Cachexia, Sarcopenia and Muscle. 8 (2), pp. 267 - 276. https://doi.org/10.1002/jcsm.12137
AuthorsSnijders, Tim, Nederveen, Joshua P., Joanisse, Sophie, Leenders, Marika, Verdijk, Lex B., Van Loon, Luc J. C. and Parise, Gianni
Abstract

Background Adequate muscle fibre perfusion is critical for the maintenance of muscle mass, it is essential in the rapid delivery of oxygen, nutrients and growth factors to the muscle, stimulating muscle fibre growth. Muscle fibre capillarization is known to decrease substantially with advancing age. However, whether (relative) low muscle fibre capillarization negatively impacts the muscle hypertrophic response following resistance exercise training in older adults is unknown. Methods Twenty-two healthy older men (71 ± 1 years) performed 24 weeks of progressive resistance type exercise training. To assess the change in muscle fibre characteristics, percutaneous biopsies from the vastus lateralis muscle were taken before and following 12 and 24 weeks of the intervention programme. A comparison was made between participants who had a relatively low type II muscle fibre capillary-to-fibre perimeter exchange index (CFPE, LOW group) and high type II muscle fibre CFPE (HIGH group) at baseline. Type I and type II muscle fibre size, satellite cell, capillary content and distance between satellite cells to the nearest capillary were determined by immunohistochemistry. Results Overall, type II muscle fibre size (from 5150 ± 234 to 6719 ± 446 µm2, P  <  0.05) and satellite cell content (from 0.058 ± 0.006 to 0.090 ± 0.010 satellite cells per muscle fibre, P  <  0.05) had increased significantly in response to 24 weeks of resistance exercise training. However, these improvements where mainly driven by differences in baseline type II muscle fibre capillarization, whereas muscle fibre size (from 5170 ± 390 to 7133 ± 314 µm2, P  <  0.05) and satellite cell content (from 0.059 ± 0.009 to 0.102 ± 0.017 satellite cells per muscle fibre, P  <  0.05) increased significantly in the HIGH group, no significant changes were observed in LOW group following exercise training. No significant changes in type I and type II muscle fibre capillarization were observed in response to 12 and 24 weeks of resistance exercise training in both the LOW and HIGH group. Conclusions Type II muscle fibre capillarization at baseline may be a critical factor for allowing muscle fibre hypertrophy to occur during prolonged resistance exercise training in older men.

Keywordscapillary; exercise training; elderly; fibre growth; skeletal muscle
Year2016
JournalJournal of Cachexia, Sarcopenia and Muscle
Journal citation8 (2), pp. 267 - 276
PublisherWiley - V C H Verlag GmbH & Co. KGaA
ISSN2190-5991
Digital Object Identifier (DOI)https://doi.org/10.1002/jcsm.12137
Scopus EID2-s2.0-84980373814
Open accessOpen access
Page range267 - 276
Research GroupMary MacKillop Institute for Health Research
Publisher's version
License
Place of publicationGermany
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