The fifth element in drug design: Boron in medicinal chemistry

Journal article


Kahlert, Jan, Austin, Christopher J. D., Kassiou, Michael and Rendina, Louis M.. (2013). The fifth element in drug design: Boron in medicinal chemistry. Australian Journal of Chemistry. 66(10), pp. 1118 - 1123. https://doi.org/10.1071/CH13256
AuthorsKahlert, Jan, Austin, Christopher J. D., Kassiou, Michael and Rendina, Louis M.
Abstract

The unique chemistry of boron allows for the utilisation of novel building-blocks which are not traditionally found in medicinal chemistry. The pharmaceutical industry has begun to exploit boronic acid derivatives as new drugs and several research groups are also exploring 1,2-azaborines and icosahedral boranes known as carboranes as boron-based structural motifs, with great promise for innovative drug design. Recent advances in the medicinal chemistry of these three important boron moieties are highlighted and illustrated with selected examples.

Year2013
JournalAustralian Journal of Chemistry
Journal citation66 (10), pp. 1118 - 1123
PublisherCSIRO Publishing
ISSN0004-9425
Digital Object Identifier (DOI)https://doi.org/10.1071/CH13256
Scopus EID2-s2.0-84885081884
Page range1118 - 1123
Research GroupSchool of Behavioural and Health Sciences
Publisher's version
File Access Level
Controlled
Place of publicationAustralia
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https://acuresearchbank.acu.edu.au/item/8990w/the-fifth-element-in-drug-design-boron-in-medicinal-chemistry

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