Astaxanthin supplementation does not augment fat use or improve endurance performance

Journal article


Res, Peter T., Cermak, Naomi, Stinkens, Rudi, Tollakson, T. J., Haenen, Guido R., Bast, Aalt and Van Loon, Luc J.C. 2013. Astaxanthin supplementation does not augment fat use or improve endurance performance. Medicine and Science in Sports and Exercise. 45 (6), pp. 1158 - 1165. https://doi.org/10.1249/MSS.0b013e31827fddc4
AuthorsRes, Peter T., Cermak, Naomi, Stinkens, Rudi, Tollakson, T. J., Haenen, Guido R., Bast, Aalt and Van Loon, Luc J.C.
Abstract

RES, P. T., N. M. CERMAK, R. STINKENS, T. J. TOLLAKSON, G. R. HAENEN, A. BAST, and L. J. VAN LOON. Astaxanthin Supplementation Does Not Augment Fat Use or Improve Endurance Performance. Med. Sci. Sports Exerc., Vol. 45, No. 6, pp. 1158–1165, 2013. Introduction: Astaxanthin is a lipid-soluble carotenoid found in a variety of aquatic organisms. Prolonged astaxanthin supplementation has been reported to increase fat oxidative capacity and improve running time to exhaustion in mice. These data suggest that astaxanthin may be applied as a potent ergogenic aid in humans. Purpose: To assess the effect of 4 wk of astaxanthin supplementation on substrate use and subsequent time trial performance in well-trained cyclists. Methods: Using a double-blind parallel design, 32 young, well-trained male cyclists or triathletes (age = 25 T 1 yr, weight = 73 T 1 kg, V˙ O2peak = 60 T 1 mLj1 Ikgj1 Iminj1 , Wmax = 395 T 7 W; mean T SEM) were supplemented for 4 wk with 20 mg of astaxanthin per day (ASTA) or a placebo (PLA). Before and after the supplementation period, subjects performed 60 min of exercise (50% Wmax), followed by an time trial of approximately 1 h. Results: Daily astaxanthin supplementation significantly increased basal plasma astaxanthin concentrations from nondetectable values to 187 T 19 KgIkgj1 (P G 0.05). This elevation was not reflected in greater total plasma antioxidant capacity (P = 0.90) or attenuated malondialdehyde levels (P = 0.63). Whole-body fat oxidation rates during submaximal exercise did not differ between groups and did not change over time (from 0.71 T 0.04 to 0.68 T 0.03 gIminj1 and from 0.66 T 0.04 to 0.61 T 0.05 gIminj1 in the PLA and ASTA groups, respectively; P = 0.73). No improvements in time trial performance were observed in either group (from 236 T 9 to 239 T 7 and from 238 T 6 to 244 T 6 W in the PLA and ASTA groups, respectively; P = 0.63). Conclusion: Prolonged astaxanthin supplementation does not augment antioxidant capacity, increase fat oxidative capacity, or improve time trial performance in trained cyclists. Key Words: SUBSTRATE USE, CYCLING, FAT OXIDATION, EXERCISE, ERGOGENIC AIDS, ANTI-OXIDANTS

Year2013
JournalMedicine and Science in Sports and Exercise
Journal citation45 (6), pp. 1158 - 1165
PublisherLippincott Williams and Wilkins
ISSN0195-9131
Digital Object Identifier (DOI)https://doi.org/10.1249/MSS.0b013e31827fddc4
Scopus EID2-s2.0-84878942577
Page range1158 - 1165
Research GroupMary MacKillop Institute for Health Research
Place of publicationUnited States
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