Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise

Journal article


Li, Mengyao, Verdijk, Lex B., Sakamoto, Kei, Ely, Brian, Van Loon, Luc J.C. and Musi, Nicolas. (2012). Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise. Mechanisms of Ageing and Development. 133(2017-12-11), pp. 655 - 664. https://doi.org/10.1016/j.mad.2012.09.001
AuthorsLi, Mengyao, Verdijk, Lex B., Sakamoto, Kei, Ely, Brian, Van Loon, Luc J.C. and Musi, Nicolas
Abstract

AMP-activated protein kinase (AMPK) is a key energy-sensitive enzyme that controls numerous metabolic and cellular processes. Mammalian target of rapamycin (mTOR) is another energy/nutrientsensitive kinase that controls protein synthesis and cell growth. In this study we determined whether older versus younger men have alterations in the AMPK and mTOR pathways in skeletal muscle, and examined the effect of a long term resistance type exercise training program on these signaling intermediaries. Older men had decreased AMPKa2 activity and lower phosphorylation of AMPK and its downstream signaling substrate acetyl-CoA carboxylase (ACC). mTOR phosphylation also was reduced in muscle from older men. Exercise training increased AMPKa1 activity in older men, however, AMPKa2 activity, and the phosphorylation of AMPK, ACC and mTOR, were not affected. In conclusion, older men have alterations in the AMPK-ACC and mTOR pathways in muscle. In addition, prolonged resistance type exercise training induces an isoform-selective up regulation of AMPK activity.

KeywordsAging; Skeletal muscle; AMPK; mTOR; Resistance exercise
Year2012
JournalMechanisms of Ageing and Development
Journal citation133 (2017-12-11), pp. 655 - 664
PublisherElsevier Ireland Ltd.
ISSN0047-6374
Digital Object Identifier (DOI)https://doi.org/10.1016/j.mad.2012.09.001
Scopus EID2-s2.0-84870756683
Page range655 - 664
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Place of publicationIreland
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