Microvascular dilator function in athletes: A systematic review and meta-analysis
Journal article
Montero, David, Walther, Guillaume, Diaz-Canestro, Candela, Pyke, Kyra E. and Padilla, Jaume. (2015). Microvascular dilator function in athletes: A systematic review and meta-analysis. Medicine and Science in Sports and Exercise. 47(7), pp. 1485 - 1494. https://doi.org/10.1249/MSS.0000000000000567
Authors | Montero, David, Walther, Guillaume, Diaz-Canestro, Candela, Pyke, Kyra E. and Padilla, Jaume |
---|---|
Abstract | Purpose: Despite the growing research interest in vascular adaptations to exercise training over the last few decades, it remains unclear whether microvascular function in healthy subjects can be further improved by regular training. Herein, we sought to systematically review the literature and determine whether microvascular dilator function is greater in athletes compared to age-matched healthy untrained subjects. Methods: We conducted a systematic search of MEDLINE, Cochrane, EMBASE, and Web of Science since their inceptions until October 2013 for articles evaluating indices of primarily microvascular endothelium-dependent or endothelium-independent dilation (MVEDD and MVEID, respectively) in athletes. A meta-analysis was performed to determine the standardized mean difference (SMD) in MVEDD and MVEID between athletes and age-matched controls. Subgroup analyses were used to study potential moderating factors. Results: Thirty-six studies were selected after systematic review, comprising 521 athletes (506 endurance-trained and 15 endurance- and strength-trained) and 496 age-matched control subjects. After data pooling, athletes presented higher MVEDD (31 studies; SMD, 0.47; P < 0.00001) and MVEID (14 studies; SMD, 0.51; P < 0.00001) compared with the control subjects. Similar results were observed in young (younger than 40 yr) and master (older than 55 yr) athletes when analyzed separately. Conclusion: Both young and master athletes present enhanced microvascular function compared with age-matched untrained but otherwise healthy subjects. These data provide evidence of a positive association between exercise training and microvascular function in the absence of known underlying cardiovascular disease. |
Keywords | microvascular function; resistance vessels; exercise training; meta-analysis |
Year | 2015 |
Journal | Medicine and Science in Sports and Exercise |
Journal citation | 47 (7), pp. 1485 - 1494 |
Publisher | Lippincott Williams & Wilkins |
ISSN | 0195-9131 |
Digital Object Identifier (DOI) | https://doi.org/10.1249/MSS.0000000000000567 |
Scopus EID | 2-s2.0-84941764191 |
Page range | 1485 - 1494 |
Research Group | Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre |
Publisher's version | File Access Level Controlled |
Place of publication | United States of America |
https://acuresearchbank.acu.edu.au/item/8q805/microvascular-dilator-function-in-athletes-a-systematic-review-and-meta-analysis
Restricted files
Publisher's version
62
total views0
total downloads0
views this month0
downloads this month