Microvascular dilator function in athletes: A systematic review and meta-analysis

Journal article

Montero, David, Walther, Guillaume, Diaz-Canestro, Candela, Pyke, Kyra E. and Padilla, Jaume. (2015) Microvascular dilator function in athletes: A systematic review and meta-analysis. Medicine and Science in Sports and Exercise. 47(7), pp. 1485 - 1494. https://doi.org/10.1249/MSS.0000000000000567
AuthorsMontero, David, Walther, Guillaume, Diaz-Canestro, Candela, Pyke, Kyra E. and Padilla, Jaume

Purpose: Despite the growing research interest in vascular adaptations to exercise training over the last few decades, it remains unclear whether microvascular function in healthy subjects can be further improved by regular training. Herein, we sought to systematically review the literature and determine whether microvascular dilator function is greater in athletes compared to age-matched healthy untrained subjects. Methods: We conducted a systematic search of MEDLINE, Cochrane, EMBASE, and Web of Science since their inceptions until October 2013 for articles evaluating indices of primarily microvascular endothelium-dependent or endothelium-independent dilation (MVEDD and MVEID, respectively) in athletes. A meta-analysis was performed to determine the standardized mean difference (SMD) in MVEDD and MVEID between athletes and age-matched controls. Subgroup analyses were used to study potential moderating factors. Results: Thirty-six studies were selected after systematic review, comprising 521 athletes (506 endurance-trained and 15 endurance- and strength-trained) and 496 age-matched control subjects. After data pooling, athletes presented higher MVEDD (31 studies; SMD, 0.47; P < 0.00001) and MVEID (14 studies; SMD, 0.51; P < 0.00001) compared with the control subjects. Similar results were observed in young (younger than 40 yr) and master (older than 55 yr) athletes when analyzed separately. Conclusion: Both young and master athletes present enhanced microvascular function compared with age-matched untrained but otherwise healthy subjects. These data provide evidence of a positive association between exercise training and microvascular function in the absence of known underlying cardiovascular disease.

Keywordsmicrovascular function; resistance vessels; exercise training; meta-analysis
JournalMedicine and Science in Sports and Exercise
Journal citation47 (7), pp. 1485 - 1494
PublisherLippincott Williams and Wilkins
Digital Object Identifier (DOI)https://doi.org/10.1249/MSS.0000000000000567
Scopus EID2-s2.0-84941764191
Page range1485 - 1494
Research GroupSports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre
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Place of publicationUnited States of America
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