Associations of physical activity and television viewing time with retinal vascular caliber in a multiethnic asian population
Journal article
Anuradha, Hayley, Lally, James, Galic, Sandra, Thomas, Melissa, Azizi, Paymon, Fullerton, Morgan, Smith, Brennan, Pulinilkunnil, Thomas, Chen, Zhi-Ping, Samaan, M Constantine, Jorgensen, Sebastian, Hawke, Thomas and Van Dender, . (2014). Associations of physical activity and television viewing time with retinal vascular caliber in a multiethnic asian population. Investigative Ophthalmology and Visual Science. 57(8), pp. 1693 - 1702. https://doi.org/10.1167/iovs.11-7324
Authors | Anuradha, Hayley, Lally, James, Galic, Sandra, Thomas, Melissa, Azizi, Paymon, Fullerton, Morgan, Smith, Brennan, Pulinilkunnil, Thomas, Chen, Zhi-Ping, Samaan, M Constantine, Jorgensen, Sebastian, Hawke, Thomas and Van Dender, |
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Abstract | Aims/hypothesis: Obesity is characterised by lipid accumulation in skeletal muscle, which increases the risk of developing insulin resistance and type 2 diabetes. AMP-activated protein kinase (AMPK) is a sensor of cellular energy status and is activated in skeletal muscle by exercise, hormones (leptin, adiponectin, IL-6) and pharmacological agents (5-amino-4-imidazolecarboxamide ribonucleoside [AICAR] and metformin). Phosphorylation of acetyl-CoA carboxylase 2 (ACC2) at S221 (S212 in mice) by AMPK reduces ACC activity and malonyl-CoA content but the importance of the AMPK–ACC2–malonyl-CoA pathway in controlling fatty acid metabolism and insulin sensitivity is not understood; therefore, we characterised Acc2 S212A knock-in (ACC2 KI) mice. |
Year | 2014 |
Journal | Investigative Ophthalmology and Visual Science |
Journal citation | 57 (8), pp. 1693 - 1702 |
ISSN | 0012-186X |
Digital Object Identifier (DOI) | https://doi.org/10.1167/iovs.11-7324 |
Page range | 1693 - 1702 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
https://acuresearchbank.acu.edu.au/item/8qw04/associations-of-physical-activity-and-television-viewing-time-with-retinal-vascular-caliber-in-a-multiethnic-asian-population
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