Associations of physical activity and television viewing time with retinal vascular caliber in a multiethnic asian population

Journal article


Anuradha, Hayley, Lally, James, Galic, Sandra, Thomas, Melissa, Azizi, Paymon, Fullerton, Morgan, Smith, Brennan, Pulinilkunnil, Thomas, Chen, Zhi-Ping, Samaan, M Constantine, Jorgensen, Sebastian, Hawke, Thomas and Van Dender, . (2014). Associations of physical activity and television viewing time with retinal vascular caliber in a multiethnic asian population. Investigative Ophthalmology and Visual Science. 57(8), pp. 1693 - 1702. https://doi.org/10.1167/iovs.11-7324
AuthorsAnuradha, Hayley, Lally, James, Galic, Sandra, Thomas, Melissa, Azizi, Paymon, Fullerton, Morgan, Smith, Brennan, Pulinilkunnil, Thomas, Chen, Zhi-Ping, Samaan, M Constantine, Jorgensen, Sebastian, Hawke, Thomas and Van Dender,
Abstract

Aims/hypothesis: Obesity is characterised by lipid accumulation in skeletal muscle, which increases the risk of developing insulin resistance and type 2 diabetes. AMP-activated protein kinase (AMPK) is a sensor of cellular energy status and is activated in skeletal muscle by exercise, hormones (leptin, adiponectin, IL-6) and pharmacological agents (5-amino-4-imidazolecarboxamide ribonucleoside [AICAR] and metformin). Phosphorylation of acetyl-CoA carboxylase 2 (ACC2) at S221 (S212 in mice) by AMPK reduces ACC activity and malonyl-CoA content but the importance of the AMPK–ACC2–malonyl-CoA pathway in controlling fatty acid metabolism and insulin sensitivity is not understood; therefore, we characterised Acc2 S212A knock-in (ACC2 KI) mice.

Year2014
JournalInvestigative Ophthalmology and Visual Science
Journal citation57 (8), pp. 1693 - 1702
ISSN0012-186X
Digital Object Identifier (DOI)https://doi.org/10.1167/iovs.11-7324
Page range1693 - 1702
Research GroupMary MacKillop Institute for Health Research
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