The diurnal pattern of salivary IL-1β in healthy young adults
Journal article
Ghazali, Nur B., Steele, Mike, Koh, David and Idris, Adi. (2017). The diurnal pattern of salivary IL-1β in healthy young adults. International Journal of Adolescent Medicine and Health. IN-PRESS(IN-PRESS), pp. 1 - 6. https://doi.org/10.1515/ijamh-2017-0058
Authors | Ghazali, Nur B., Steele, Mike, Koh, David and Idris, Adi |
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Abstract | Disruption in circadian rhythm affects the production of inflammatory cytokines. Understanding how it behaves in diseased conditions is essential. Despite the role of the interleukin-1β (IL-1β), a potent inflammatory cytokine, in human diseases, little is known about the steady-state circadian rhythm of IL-1β in healthy individuals. This short study investigates the diurnal pattern of salivary IL-1β throughout the day in healthy young adults. Twelve participants provided saliva samples at various times throughout the day. Salivary IL-1β were assessed using enzyme-linked immunosorbent assay (ELISA) and Western blot analysis. Salivary IL-1β levels were highest at 0430 h and lowest at 0000 h and shared a similar diurnal pattern to that of salivary IL-6. Western blot analysis showed that these levels correspond to the mature form of IL-1β. Our findings are important as it established the diurnal pattern of salivary IL-1β is fluctuating normally throughout the day. The findings also open an incredible opportunity for developing research conducted in the field with saliva as the diagnostic tool. |
Year | 2017 |
Journal | International Journal of Adolescent Medicine and Health |
Journal citation | IN-PRESS (IN-PRESS), pp. 1 - 6 |
Publisher | De Gruyter |
ISSN | 0334-0139 |
Digital Object Identifier (DOI) | https://doi.org/10.1515/ijamh-2017-0058 |
Scopus EID | 2-s2.0-85033609012 |
Page range | 1 - 6 |
Research Group | School of Allied Health |
Publisher's version | File Access Level Controlled |
Place of publication | Germany |
Editors | J. Merrick and J. |
https://acuresearchbank.acu.edu.au/item/8qy05/the-diurnal-pattern-of-salivary-il-1-in-healthy-young-adults
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