Serum calcium and the calcium-sensing receptor polymorphism rs17251221 in relation to coronary heart disease, type 2 diabetes, cancer and mortality: the Tromsø Study

Journal article


Jorde, Rolf, Schirmer, Henrik, Njolstad, I., Loechen, Maja-Lisa, Mathiesen, E. B., Kamycheva, Elena, Figenschau, Yngve and Grimnes, Guri. (2013) Serum calcium and the calcium-sensing receptor polymorphism rs17251221 in relation to coronary heart disease, type 2 diabetes, cancer and mortality: the Tromsø Study. European Journal of Epidemiology. 28(7), pp. 569 - 578. https://doi.org/10.1007/s10654-013-9822-y
AuthorsJorde, Rolf, Schirmer, Henrik, Njolstad, I., Loechen, Maja-Lisa, Mathiesen, E. B., Kamycheva, Elena, Figenschau, Yngve and Grimnes, Guri
Abstract

Serum calcium measured in 27,158 subjects in 1994 and the calcium-sensing receptor polymorphism rs17251221 genotyped in 9,404 subjects were related to cardiovascular risk factors, incident myocardial infarction (MI), type 2 diabetes (T2DM), cancer and death during follow-up until 2008–2010. In a Cox regression model with adjustment for age, gender, smoking and body mass index, subjects with serum calcium 2.50–2.60 mmol/L had a significantly increased risk of incident MI [n = 1,802, hazards ratio (HR) 1.40, 95 % confidence interval (CI) 1.18, 1.66] and T2DM (n = 705, HR 1.49, 95 % CI 1.15, 1.94) and a significantly reduced risk of cancer (n = 2,222, HR 0.73, 95 % CI 0.62, 0.86) as compared to subjects with serum calcium 2.20–2.29 mmol/L. For rs17251221 there was a mean difference in serum calcium of 0.05 mmol/L between major and minor homozygote genotypes. No consistent, significant relation between rs17251221 and risk factors or the major hard endpoints were found. The minor homozygote genotype (high serum calcium) had a significant twofold increased risk (HR 2.32, 95 % CI 1.24, 4.36) for prostate cancer, as compared to the major homozygote. This may be clinically important if confirmed in other cohorts.

KeywordsCalcium-sensing receptor; Cancer; Cardiovascular disease; Mortality; Prostate cancer; Serum calcium
Year2013
JournalEuropean Journal of Epidemiology
Journal citation28 (7), pp. 569 - 578
PublisherSpringer Netherlands
ISSN0393-2990
Digital Object Identifier (DOI)https://doi.org/10.1007/s10654-013-9822-y
Scopus EID2-s2.0-84884281447
Page range569 - 578
Research GroupMary MacKillop Institute for Health Research
Place of publicationNetherlands
Permalink -

https://acuresearchbank.acu.edu.au/item/8qzq3/serum-calcium-and-the-calcium-sensing-receptor-polymorphism-rs17251221-in-relation-to-coronary-heart-disease-type-2-diabetes-cancer-and-mortality-the-troms-study

Restricted files

Publisher's version

  • 3
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as