Serum 25-Hydroxyvitamin D is associated with cognitive executive function in dutch prefrail and frail elderly: A cross-sectional study exploring the associations of 25-hydroxyvitamin D with glucose metabolism, cognitive performance and depression

Journal article


Brouwer-Brolsma, Elske M., Van De Rest, Ondine, Tieland, Michael, Van Der Zwalu, Nikita L., Steegenga, Wilma T., Adam, Jos J., Van Loon, Luc J.C., Feskens, Edith J.M. and de Groot, Lisette C. P. G. M.. (2013). Serum 25-Hydroxyvitamin D is associated with cognitive executive function in dutch prefrail and frail elderly: A cross-sectional study exploring the associations of 25-hydroxyvitamin D with glucose metabolism, cognitive performance and depression. Journal of the American Medical Directors Association. 14(11), pp. 9 - 17. https://doi.org/10.1016/j.jamda.2013.06.010
AuthorsBrouwer-Brolsma, Elske M., Van De Rest, Ondine, Tieland, Michael, Van Der Zwalu, Nikita L., Steegenga, Wilma T., Adam, Jos J., Van Loon, Luc J.C., Feskens, Edith J.M. and de Groot, Lisette C. P. G. M.
Abstract

Objectives: The primary objective was to explore the possible association of serum 25-hydroxyvitamin D (25[OH]D) and vitamin D intake with markers of glucose metabolism, depression, and cognitive performance. In addition, we examined to what extent the associations between vitamin D and cognitive performance were modified or mediated by fasting plasma glucose (FPG) levels. Design, Setting, and Participants: Cross-sectional study using data of 127 frail or prefrail Dutch elderly, aged 65 years or older. Frailty was defined according to the criteria of Fried and colleagues. A participant was classified prefrail when 1 to 2 criteria were met; frailty was classified as the presence of 3 or more criteria. Measurements: Associations of 25(OH)D and vitamin D intake with markers of glucose metabolism and domain-specific cognitive performance were examined by multivariable regression analyses. The possible association of vitamin D with depression and global cognitive performance was explored by Poisson regression. Results: No associations were observed for 25(OH)D with FPG, fasting plasma insulin (FPI), Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR), or depression. In contrast, serum 25(OH)D was positively associated with executive functioning (b 0.007, P ¼ .01) and tended to be associated with information-processing speed (b 0.006, P ¼ .06). FPG did not modify or mediate these associations. Vitamin D intake was not associated with cognitive performance, glucose metabolism, or depression. Conclusion: This cross-sectional study suggests an association of serum 25(OH)D with domain-specific cognitive performance, in particular executive functioning and possibly information-processing speed, but not with FPG, FPI, HOMA-IR, or depression. Whether these associations are causal is yet to be demonstrated.

KeywordsVitamin D; glucose metabolism; cognition; depression; aging; cross-sectional
Year2013
JournalJournal of the American Medical Directors Association
Journal citation14 (11), pp. 9 - 17
PublisherElsevier Inc.
ISSN1525-8610
Digital Object Identifier (DOI)https://doi.org/10.1016/j.jamda.2013.06.010
Scopus EID2-s2.0-84886770010
Page range9 - 17
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Place of publicationUnited States
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