Home-based pulmonary rehabilitation early after hospitalisation in COPD (early HomeBase) : Protocol for a randomised controlled trial

Journal article


Cox, Narelle, Lahham, Aroub, McDonald, Christine F., Mahal, Ajay, O'Halloran, Paul, Hepworth, Graham, Spencer, Lissa, McNamara, Renae J., Bondarenko, Janet, Macdonald, Heather, Gavin, Samantha, Burge, Angela T., Luxton, Nia Angharad and et. al.. (2021). Home-based pulmonary rehabilitation early after hospitalisation in COPD (early HomeBase) : Protocol for a randomised controlled trial. BMJ Open Respiratory Research. 8(1), pp. 1-9. https://doi.org/10.1136/bmjresp-2021-001107
AuthorsCox, Narelle, Lahham, Aroub, McDonald, Christine F., Mahal, Ajay, O'Halloran, Paul, Hepworth, Graham, Spencer, Lissa, McNamara, Renae J., Bondarenko, Janet, Macdonald, Heather, Gavin, Samantha, Burge, Angela T., Luxton, Nia Angharad and et. al.
Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) is characterised by exacerbations of respiratory disease, frequently requiring hospital admission. Pulmonary rehabilitation can reduce the likelihood of future hospitalisation, but programme uptake is poor. This study aims to compare hospital readmission rates, clinical outcomes and costs between people with COPD who undertake a home-based programme of pulmonary rehabilitation commenced early (within 2 weeks) of hospital discharge with usual care.

Methods: A multisite randomised controlled trial, powered for superiority, will be conducted in Australia. Eligible patients admitted to one of the participating sites for an exacerbation of COPD will be invited to participate. Participants will be randomised 1:1. Intervention group participants will undertake an 8-week programme of home-based pulmonary rehabilitation commencing within 2 weeks of hospital discharge. Control group participants will receive usual care and a weekly phone call for attention control. Outcomes will be measured by a blinded assessor at baseline, after the intervention (week 9–10 posthospital discharge), and at 12 months follow-up. The primary outcome is hospital readmission at 12 months follow-up.

Ethics and dissemination: Human Research Ethics approval for all sites provided by Alfred Health (Project 51216). Findings will be published in peer-reviewed journals, conferences and lay publications.

Trial registration number: ACTRN12619001122145.

KeywordsChronic obstructive pulmonary disease; COPD; respiratory disease; pulmonary rehabilitation; hospitalisation; Australia
Year01 Jan 2021
JournalBMJ Open Respiratory Research
Journal citation8 (1), pp. 1-9
PublisherBMJ Publishing Group
ISSN2052-4439
Digital Object Identifier (DOI)https://doi.org/10.1136/bmjresp-2021-001107
Web address (URL)https://bmjopenrespres.bmj.com/content/8/1/e001107
Open accessOpen access
Research or scholarlyResearch
Page range1-9
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Open
Output statusPublished
Publication dates
Online24 Nov 2021
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Deposited21 Nov 2024
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Open
Supplemental file
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© Author(s) (or their employer(s)) 2021

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non- commercial. See: http:// creativecommons. org/ licenses/ by- nc/ 4. 0/.

Place of publicationUnited Kingdom
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