Effect of dietary intervention, with or without cointerventions, on inflammatory markers in patients with nonalcoholic fatty liver disease : A systematic review and meta-analysis

Journal article


Hall, Renate L., George, Elena S., Tierney, Audrey C. and Reddy, Anj. (2023). Effect of dietary intervention, with or without cointerventions, on inflammatory markers in patients with nonalcoholic fatty liver disease : A systematic review and meta-analysis. Advances in Nutrition. 14(3), pp. 475-499. https://doi.org/10.1016/j.advnut.2023.01.001
AuthorsHall, Renate L., George, Elena S., Tierney, Audrey C. and Reddy, Anj
Abstract

Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease from simple steatosis to nonalcoholic steatohepatitis, with inflammatory cytokines and adipokines identified as drivers of disease progression. Poor dietary patterns are known to promote an inflammatory milieu, although the effects of specific diets remain largely unknown. This review aimed to gather and summarize new and existing evidence on the effect of dietary intervention on inflammatory markers in patients with NAFLD. The electronic databases MEDLINE, EMBASE, CINAHL, and Cochrane were searched for clinical trials which investigated outcomes of inflammatory cytokines and adipokines. Eligible studies included adults >18 y with NAFLD, which compared a dietary intervention with an alternative diet or control (no intervention) group or were accompanied by supplementation or other lifestyle interventions. Outcomes for inflammatory markers were grouped and pooled for meta-analysis where heterogeneity was allowed. Methodological quality and risk of bias were assessed using the Academy of Nutrition and Dietetics Criteria. Overall, 44 studies with a total of 2579 participants were included. Meta-analyses indicated intervention with an isocaloric diet plus supplement was more effective in reducing C-reactive protein (CRP) [standard mean difference (SMD): 0.44; 95% CI: 0.20, 0.68; P = 0.0003] and tumor necrosis factor-alpha (TNF-α) (SMD: 0.74; 95% CI: 0.02, 1.46; P = 0.03) than an isocaloric diet alone. No significant weighting was shown between a hypocaloric diet with or without supplementation for CRP (SMD: 0.30; 95% CI: −0.84, 1.44; P = 0.60) and TNF-α (SMD: 0.01; 95% CI: −0.43, 0.45; P = 0.97). In conclusion, hypocaloric and energy-restricted diets alone or with supplementation, and isocaloric diets with supplementation were shown to be most effective in improving the inflammatory profile of patients with NAFLD. To better determine the effectiveness of dietary intervention alone on a NAFLD population, further investigations of longer durations, with larger sample sizes are required.

Keywordsadipokines; cytokines; dietary patterns; diet; inflammation; inflammatory markers; nonalcoholic fatty liver disease; nutrition
Year2023
JournalAdvances in Nutrition
Journal citation14 (3), pp. 475-499
PublisherElsevier Inc.
ISSN2161-8313
Digital Object Identifier (DOI)https://doi.org/10.1016/j.advnut.2023.01.001
PubMed ID36796436
Scopus EID2-s2.0-85150305939
PubMed Central IDPMC10201675
Open accessPublished as ‘gold’ (paid) open access
Page range475-499
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online12 May 2023
Publication process dates
Accepted06 Jan 2023
Deposited30 Mar 2025
Additional information

© 2023 The Author(s). Published by Elsevier Inc. on behalf of American Society for Nutrition. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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License: CC BY-NC-ND 4.0
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