Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance?
Journal article
Carmichael, Lauren, Keske, Michelle A., Betik, Andrew C., Parker, Lewan, Brayner, Barbara, Roberts-Thomson, Katherine M., Wadley, Glen D., Hamilton, D. Lee and Kaur, Gunveen. (2022). Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance? Nutrition and Diabetes. 12(1), p. Article 31. https://doi.org/10.1038/s41387-022-00209-z
Authors | Carmichael, Lauren, Keske, Michelle A., Betik, Andrew C., Parker, Lewan, Brayner, Barbara, Roberts-Thomson, Katherine M., Wadley, Glen D., Hamilton, D. Lee and Kaur, Gunveen |
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Abstract | There is increasing evidence that skeletal muscle microvascular (capillary) blood flow plays an important role in glucose metabolism by increasing the delivery of glucose and insulin to the myocytes. This process is impaired in insulin-resistant individuals. Studies suggest that in diet-induced insulin-resistant rodents, insulin-mediated skeletal muscle microvascular blood flow is impaired post-short-term high fat feeding, and this occurs before the development of myocyte or whole-body insulin resistance. These data suggest that impaired skeletal muscle microvascular blood flow is an early vascular step before the onset of insulin resistance. However, evidence of this is still lacking in humans. In this review, we summarise what is known about short-term high-calorie and/or high-fat feeding in humans. We also explore selected animal studies to identify potential mechanisms. We discuss future directions aimed at better understanding the ‘early’ vascular mechanisms that lead to insulin resistance as this will provide the opportunity for much earlier screening and timing of intervention to assist in preventing type 2 diabetes. |
Year | 2022 |
Journal | Nutrition and Diabetes |
Journal citation | 12 (1), p. Article 31 |
Publisher | Nature Publishing Group |
ISSN | 2044-4052 |
Digital Object Identifier (DOI) | https://doi.org/10.1038/s41387-022-00209-z |
PubMed ID | 35676248 |
Scopus EID | 2-s2.0-85131640501 |
PubMed Central ID | PMC9177754 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1-12 |
Funder | National Health and Medical Research Council (NHMRC) |
National Heart Foundation of Australia | |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 08 Jun 2022 |
Publication process dates | |
Accepted | 25 May 2022 |
Deposited | 30 Mar 2025 |
Additional information | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
https://acuresearchbank.acu.edu.au/item/91824/is-vascular-insulin-resistance-an-early-step-in-diet-induced-whole-body-insulin-resistance
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Publisher's version
OA_Carmichael_2022_Is_vascular_insulin_resistance_an_early.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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