Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance?

Journal article


Carmichael, Lauren, Keske, Michelle A., Betik, Andrew C., Parker, Lewan, Brayner, Barbara, Roberts-Thomson, Katherine M., Wadley, Glen D., Hamilton, D. Lee and Kaur, Gunveen. (2022). Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance? Nutrition and Diabetes. 12(1), p. Article 31. https://doi.org/10.1038/s41387-022-00209-z
AuthorsCarmichael, Lauren, Keske, Michelle A., Betik, Andrew C., Parker, Lewan, Brayner, Barbara, Roberts-Thomson, Katherine M., Wadley, Glen D., Hamilton, D. Lee and Kaur, Gunveen
Abstract

There is increasing evidence that skeletal muscle microvascular (capillary) blood flow plays an important role in glucose metabolism by increasing the delivery of glucose and insulin to the myocytes. This process is impaired in insulin-resistant individuals. Studies suggest that in diet-induced insulin-resistant rodents, insulin-mediated skeletal muscle microvascular blood flow is impaired post-short-term high fat feeding, and this occurs before the development of myocyte or whole-body insulin resistance. These data suggest that impaired skeletal muscle microvascular blood flow is an early vascular step before the onset of insulin resistance. However, evidence of this is still lacking in humans. In this review, we summarise what is known about short-term high-calorie and/or high-fat feeding in humans. We also explore selected animal studies to identify potential mechanisms. We discuss future directions aimed at better understanding the ‘early’ vascular mechanisms that lead to insulin resistance as this will provide the opportunity for much earlier screening and timing of intervention to assist in preventing type 2 diabetes.

Year2022
JournalNutrition and Diabetes
Journal citation12 (1), p. Article 31
PublisherNature Publishing Group
ISSN2044-4052
Digital Object Identifier (DOI)https://doi.org/10.1038/s41387-022-00209-z
PubMed ID35676248
Scopus EID2-s2.0-85131640501
PubMed Central IDPMC9177754
Open accessPublished as ‘gold’ (paid) open access
Page range1-12
FunderNational Health and Medical Research Council (NHMRC)
National Heart Foundation of Australia
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online08 Jun 2022
Publication process dates
Accepted25 May 2022
Deposited30 Mar 2025
Additional information

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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