Effectiveness of a cough management algorithm at the transitional phase from acute to chronic cough in Australian children aged <15 years: Protocol for a randomised controlled trial

Journal article


O'Grady, Kerry-Ann F., Grimwood, Keith, Toombs, Maree, Sloots, Theo, Otim, Michael, Whiley, David, Anderson, Jennie, Rablin, Sheree, Torzillo, Paul J., Buntain, Helen, Connor, Anne, Adsett, Don, Kar, Oon Meng and Chang, Anne. (2017) Effectiveness of a cough management algorithm at the transitional phase from acute to chronic cough in Australian children aged <15 years: Protocol for a randomised controlled trial. BMJ Open. https://doi.org/10.1136/bmjopen-2016-013796
AuthorsO'Grady, Kerry-Ann F., Grimwood, Keith, Toombs, Maree, Sloots, Theo, Otim, Michael, Whiley, David, Anderson, Jennie, Rablin, Sheree, Torzillo, Paul J., Buntain, Helen, Connor, Anne, Adsett, Don, Kar, Oon Meng and Chang, Anne
Abstract

Introduction Acute respiratory infections (ARIs) are leading causes of hospitalisation in Australian children and, if recurrent, are associated with increased risk of chronic pulmonary disorders later in life. Chronic ( > 4 weeks) cough in children following ARI is associated with decreased quality-of-life scores and increased health and societal economic costs. We will determine whether a validated evidence-based cough algorithm, initiated when chronic cough is first diagnosed after presentation with ARI, improves clinical outcomes in children compared with usual care. Methods and analysis A multicentre, parallel group, open-label, randomised controlled trial, nested within a prospective cohort study in Southeast Queensland, Australia, is underway. 750 children aged < 15 years will be enrolled and followed weekly for 8 weeks after presenting with an ARI with cough. 214 children from this cohort with persistent cough at day 28 will be randomised to either early initiation of a cough management algorithm or usual care (107 per group). Randomisation is stratified by reason for presentation, site and total cough duration at day 28 ( < 6 and ≥6 weeks). Demographic details, risk factors, clinical histories, examination findings, cost-of-illness data, an anterior nasal swab and parent and child exhaled carbon monoxide levels (when age appropriate) are collected at enrolment. Weekly contacts will collect cough status and cost-of-illness data. Additional nasal swabs are collected at days 28 and 56. The primary outcome is time-to-cough resolution. Secondary outcomes include direct and indirect costs of illness and the predictors of chronic cough postpresentation.

Year2017
JournalBMJ Open
Digital Object Identifier (DOI)https://doi.org/10.1136/bmjopen-2016-013796
Scopus EID2-s2.0-85014908281
Open accessOpen access
Research GroupSchool of Allied Health
Publisher's version
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