Saccadic eye movements in anorexia nervosa

Journal article

Phillipou, Andrea, Rossell, Susan, Gurvich, Caroline, Hughes, Matthew Edward, Castle, David J., Nibbs, Richard Grant and Abel, Larry Allen. (2016). Saccadic eye movements in anorexia nervosa. PLoS ONE. 11(3), pp. 1 - 16. https://doi.org/10.1371/journal.pone.0152338
AuthorsPhillipou, Andrea, Rossell, Susan, Gurvich, Caroline, Hughes, Matthew Edward, Castle, David J., Nibbs, Richard Grant and Abel, Larry Allen
Abstract

Background
Anorexia Nervosa (AN) has a mortality rate among the highest of any mental illness, though the factors involved in the condition remain unclear. Recently, the potential neurobiological underpinnings of the condition have become of increasing interest. Saccadic eye movement tasks have proven useful in our understanding of the neurobiology of some other psychiatric illnesses as they utilise known brain regions, but to date have not been examined in AN. The aim of this study was to investigate whether individuals with AN differ from healthy individuals in performance on a range of saccadic eye movements tasks.
Methods
24 females with AN and 25 healthy individuals matched for age, gender and premorbid intelligence participated in the study. Participants were required to undergo memory-guided and self-paced saccade tasks, and an interleaved prosaccade/antisaccade/no-go saccade task while undergoing functional magnetic resonance imaging (fMRI).
Results
AN participants were found to make prosaccades of significantly shorter latency than healthy controls. AN participants also made an increased number of inhibitory errors on the memory-guided saccade task. Groups did not significantly differ in antisaccade, no-go saccade or self-paced saccade performance, or fMRI findings.
Discussion
The results suggest a potential role of GABA in the superior colliculus in the psychopathology of AN.

Year2016
JournalPLoS ONE
Journal citation11 (3), pp. 1 - 16
PublisherPublic Library of Science
ISSN1932-6203
Digital Object Identifier (DOI)https://doi.org/10.1371/journal.pone.0152338
Scopus EID2-s2.0-84962073202
Open accessOpen access
Page range1 - 16
Publisher's version
License
Place of publicationUnited States of America
EditorsZ. Kapoula
Permalink -

https://acuresearchbank.acu.edu.au/item/86q3w/saccadic-eye-movements-in-anorexia-nervosa

Log in to edit

Download files

Publisher's version
OA_Phillipou_2016_Saccadic_eye_movements_in_anorexia_nervosa.pdf
License: CC BY 4.0

  • 126
    total views
  • 78
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Peer mentoring for eating disorders: evaluation of a pilot program 
Jennifer Beveridge, Andrea Phillipou, Kelly Edwards, Alice Hobday, Krissy Hilton, Cathy Wyett, Anna Saw, Georgia Graham, David Castle, Leah Brennan, Philippa Harrison, Rebecca de Gier, Narelle Warren, Freya Hanly, Benjamin Torrens-Witherow and J.Richard Newton. (2018). Peer mentoring for eating disorders: evaluation of a pilot program . Pilot and Feasibility Studies. 4(1), pp. 1-9. https://doi.org/10.1186/s40814-018-0268-6
Feeling fat in eating disorders: Testing the unique relationships between feeling fat and measures of disordered eating in anorexia nervosa and bulimia nervosa
Linardon, Jake, Phillipou, Andrea, Castle, David J., Newton, Richard, Harrison, Philippa, Cistullo, Leonardo L., Griffiths, Scott, Hindle, Annemarie and Brennan, Leah. (2018). Feeling fat in eating disorders: Testing the unique relationships between feeling fat and measures of disordered eating in anorexia nervosa and bulimia nervosa. Body Image. 25, pp. 163 - 167. https://doi.org/10.1016/j.bodyim.2018.04.001
Self-reported reasons for smoking : Predicting abstinence and implications for smoking cessation treatments among those with a psychotic disorder
Clark, Vanessa, Baker, Amanda, Lewin, Terry, Richmond, Robyn, Kay-Lambkin, Frances, Filia, Sacha, Castle, David, Williams, Jill and Todd, Juanita. (2017). Self-reported reasons for smoking : Predicting abstinence and implications for smoking cessation treatments among those with a psychotic disorder. Journal of Dual Diagnosis. 13(1), pp. 6-14. https://doi.org/10.1080/15504263.2016.1271489
Exploration of health status, illness perceptions, coping strategies, psychological morbidity, and quality of life in individuals with fecal ostomies
Knowles, Simon R., Tribbick, Davina, Connell, William R., Castle, David, Salzberg, Michael and Kamm, Michael A.. (2017). Exploration of health status, illness perceptions, coping strategies, psychological morbidity, and quality of life in individuals with fecal ostomies. Journal of Wound Ostomy and Continence Nursing. 44(1), pp. 69 - 73. https://doi.org/10.1097/WON.0000000000000295
Depression screening and referral in cardiac wards: a 12-month patient trajectory
Ski, Chantal, Worrall-Carter, Linda, Cameron, Jan, Castle, David, Rahman, Aziz and Thompson, David. (2017). Depression screening and referral in cardiac wards: a 12-month patient trajectory. European Journal of Cardiovascular Nursing. 16(2), pp. 157 - 166. https://doi.org/10.1177/1474515115583617
Early origins of mental disorder: Risk factors in the perinatal and infant period
Newman, Louise, Judd, Fiona, Olsson, Craig A., Castle, David J., Bousman, Chad, Sheehan, Penelope, Pantelis, Christos, Craig, Jeffrey M., Komiti, Angela and Everall, Ian P.. (2016). Early origins of mental disorder: Risk factors in the perinatal and infant period. BMC Psychiatry. 16(1), pp. 1 - 8. https://doi.org/10.1186/s12888-016-0982-7
The Mental Health in Diabetes Service (MINDS) to enhance psychosocial health: Study protocol for a randomized controlled trial
O'Brien, Casey L., Ski, Chantal F., Thompson, David R., Moore, Gaye, Mancuso, Serafino, Jenkins, Alicia, Ward, Glenn, MacIsaac, Richard J., Loh, Margaret, Knowles, Simon R., Rossell, Susan L. and Castle, David J.. (2016). The Mental Health in Diabetes Service (MINDS) to enhance psychosocial health: Study protocol for a randomized controlled trial. Trials. 17(1), pp. 1 - 10. https://doi.org/10.1186/s13063-016-1561-4
Resting state functional connectivity in anorexia nervosa
Phillipou, Andrea, Abel, Larry Allen, Castle, David Jonathan, Hughes, Matthew Edward, Nibbs, Richard Grant, Gurvich, Caroline and Rossell, Susan Lee. (2016). Resting state functional connectivity in anorexia nervosa. Psychiatry Research: Neuroimaging. 251, pp. 45 - 52. https://doi.org/10.1016/j.pscychresns.2016.04.008
Design and protocol for the Dialysis Optimal Health Program (DOHP) randomised controlled trial
Knowles, Simon R., Ski, Chantal F., Langham, Robyn, O'Flaherty, Emmet, Thompson, David R., Rossell, Susan L., Moore, Gaye, Hsueh, Ya-Seng Arthur and Castle, David J.. (2016). Design and protocol for the Dialysis Optimal Health Program (DOHP) randomised controlled trial. Trials. 17(447), pp. 1 - 9. https://doi.org/10.1186/s13063-016-1558-z
The Stroke and Carer Optimal Health Program (SCOHP) to enhance psychosocial health: study protocol for a randomized controlled trial
Brasier, Catherine, Ski, Chantal F., Thompson, David Robert, Cameron, Janette Dorothy, O'Brien, Casey L., Lautenschlager, Nicola T., Gonzales, Graeme, Hsueh, Ya-seng Arthur, Moore, Gaye, Knowles, Simon R., Rossell, Susan L., Haselden, Rachel and Castle, David J.. (2016). The Stroke and Carer Optimal Health Program (SCOHP) to enhance psychosocial health: study protocol for a randomized controlled trial. Trials. 17(1), pp. 1 - 9. https://doi.org/10.1186/s13063-016-1559-y
Trialling of an optimal health programme (OHP) across chronic disease
Ski, Chantal, Thompson, David and Castle, David J.. (2016). Trialling of an optimal health programme (OHP) across chronic disease. Trials. 17(445), pp. 1 - 5. https://doi.org/10.1186/s13063-016-1560-5
Reducing smoking reduces suicidality among individuals with psychosis: Complementary outcomes from a Healthy Lifestyles intervention study
Sankaranarayanan, Anoop, Clark, Vanessa, Baker, Amanda, Palazzi, Kerrin, Lewin, Terry J., Richmond, Robyn, Kay-Lambkin, Frances J., Filia, Sacha, Castle, David and Willia, Jill M.. (2016). Reducing smoking reduces suicidality among individuals with psychosis: Complementary outcomes from a Healthy Lifestyles intervention study. Psychiatry Research. 243, pp. 407 - 412. https://doi.org/10.1016/j.psychres.2016.07.006
Body image in anorexia nervosa: Body size estimation utilising a biological motion task and eyetracking
Phillipou, Andrea, Rossell, Susan Lee, Gurvich, Caroline, Castle, David Jonathan, Troje, Nikolaus Friedrich and Abel, Larry Allen. (2016). Body image in anorexia nervosa: Body size estimation utilising a biological motion task and eyetracking. European Eating Disorders Review. 24(2), pp. 131 - 138. https://doi.org/10.1002/erv.2423
Randomised controlled trials of psychological and pharmacological treatments for body dysmorphic disorder: A systematic review
Phillipou, Andrea, Rossell, Susan L., Wilding, Helen E. and Castle, David J.. (2016). Randomised controlled trials of psychological and pharmacological treatments for body dysmorphic disorder: A systematic review. Psychiatry Research. 245, pp. 179 - 185. https://doi.org/10.1016/j.psychres.2016.05.062
Does collaborative case conceptualisation enhance engagement and outcome in the treatment of anorexia nervosa? Rational, design and methods
Mitchell, Sarah Anne, Newton, Richard, Harrison, Philippa, Castle, David and Brennan, Leah. (2016). Does collaborative case conceptualisation enhance engagement and outcome in the treatment of anorexia nervosa? Rational, design and methods. Contemporary Clinical Trials. 47(March), pp. 296 - 303. https://doi.org/10.1016/j.cct.2015.12.011
An integrative review of paternal depression
Edward, Karen-Leigh, Castle, David J., Mills, Cally, Davis, Leigh, Davis, Leigh and Casey, June. (2015). An integrative review of paternal depression. American Journal of Men's Health. 9(1), pp. 26 - 34. https://doi.org/10.1177/1557988314526614
A comparative study of the economic and social functioning of Vietnamese-Australians with low English proficiency living with psychotic illness
Stolk, Yvonne, Sevar, Katherine, Tran, Nga, Mancuso, Serafino G., Chopra, Prem and Castle, David. (2015). A comparative study of the economic and social functioning of Vietnamese-Australians with low English proficiency living with psychotic illness. International Journal of Social Psychiatry. 61(4), pp. 1 - 11. https://doi.org/10.1177/0020764014543710
Self perception and facial emotion perception of others in anorexia nervosa
Phillipou, Andrea, Abel, Larry Allen, Castle, David J., Hughes, Matthew Edward, Gurvich, Caroline, Nibbs, Richard Grant and Rossell, Susan L.. (2015). Self perception and facial emotion perception of others in anorexia nervosa. Frontiers in Psychology. 6, pp. 1 - 9. https://doi.org/10.3389/fpsyg.2015.01181
Applying the World Health Organization Mental Health Action Plan to evaluate policy on addressing co-occurrence of physical and mental illnesses in Australia
Happell, Brenda, Platania-Phung, Chris, Webster, Stephanie, McKenna, Brian, Millar, Freyja, Stanton, Robert, Galletly, Cherrie, Castle, David, Furness, Trentham, Liu, Dennis and Scott, David. (2015). Applying the World Health Organization Mental Health Action Plan to evaluate policy on addressing co-occurrence of physical and mental illnesses in Australia. Australian Health Review. 39(4), pp. 370 - 378. https://doi.org/10.1071/AH14098
Are personality disturbances in anorexia nervosa related to emotion processing or eating disorder symptomatology?
Phillipou, Andrea, Gurvich, Caroline, Castle, David Jonathan and Rossell, Susan Lee. (2015). Are personality disturbances in anorexia nervosa related to emotion processing or eating disorder symptomatology? Journal of Eating Disorders. 3(1), pp. 1 - 5. https://doi.org/10.1186/s40337-015-0071-1
The effectiveness of specialist roles in mental health metabolic monitoring: A retrospective cross-sectional comparison study
McKenna, Brian, Furness, Trentham, Wallace, Elizabeth, Happell, Brenda, Stanton, Robert, Platania-Phung, Chris, Edward, Karen-Leigh and Castle, David. (2014). The effectiveness of specialist roles in mental health metabolic monitoring: A retrospective cross-sectional comparison study. BMC Psychiatry. 14(234), pp. 1 - 6. https://doi.org/10.1186/s12888-014-0234-7
Exploring health care providers' perceptions of the needs of stroke carers: Informing development of an Optimal Health Program
O'Brien, Casey, Moore, Gaye, Rolley, John Xavier, Ski, Chantal, Thompson, David, Lautenschlager, Nicola, Gonzales, Graeme, Hsueh, Arthur and Castle, David. (2014). Exploring health care providers' perceptions of the needs of stroke carers: Informing development of an Optimal Health Program. Topics in Stroke Rehabilitation. 21(5), pp. 421 - 431. https://doi.org/10.1310/tsr2105-421
Using theories of delusion formation to explain abnormal beliefs in Body Dysmorphic Disorder (BDD)
Rossell, Susan L., Labuschagne, Izelle, Dunai, Judith, Kyrios, Michael and Castle, David. (2014). Using theories of delusion formation to explain abnormal beliefs in Body Dysmorphic Disorder (BDD). Psychiatry Research. 215(3), pp. 599 - 605. https://doi.org/10.1016/j.psychres.2013.12.030
Optimizing prediction of binge eating episodes: A comparison approach to test alternative conceptualizations of the affect regulation model
Fuller-Tyszkiewicz, Matthew, Richardson, Ben, Skouteris, Helen, Austin, David, Castle, David, Busija, Lucy, Klein, Britt, Holmes, Millicent and Broadbent, Jaclyn. (2014). Optimizing prediction of binge eating episodes: A comparison approach to test alternative conceptualizations of the affect regulation model. Journal of Eating Disorders. 2(28), pp. 1 - 8. https://doi.org/10.1186/s40337-014-0028-9
Exploration of health status, illness perceptions, coping strategies, and psychological morbidity in stoma patients
Knowles, Simon R., Tribbick, Davina, Connell, William R., Castle, David J., Salzberg, Michael and Kamm, Michael A.. (2014). Exploration of health status, illness perceptions, coping strategies, and psychological morbidity in stoma patients. Journal of Wound Ostomy and Continence Nursing. 41(6), pp. 573 - 580. https://doi.org/10.1097/WON.0000000000000073
Smoking behavior among patients and staff : A snapshot from a major metropolitan hospital in Melbourne, Australia
Rahman, Muhammad Aziz, Wilson, Andrew, Sanders, Rhonda, Castle, David, Daws, Karen, Thompson, David, Ski, Chantal, Matthews, Sarah, Wright, Christine and Worrall-Carter, Linda. (2014). Smoking behavior among patients and staff : A snapshot from a major metropolitan hospital in Melbourne, Australia. International Journal of General Medicine. 7, pp. 79 - 87. https://doi.org/10.2147/IJGM.S54230
Square wave jerks and anxiety as distinctive biomarkers for anorexia nervosa
Phillipou, Andrea, Rossell, Susan Lee, Castle, David Jonathan, Gurvich, Caroline and Abel, Larry Allen. (2014). Square wave jerks and anxiety as distinctive biomarkers for anorexia nervosa. Investigative Ophthalmology and Visual Science. 55(12), pp. 8366 - 8370. https://doi.org/10.1167/iovs.14-15807
A comparison of executive function in Body Dysmorphic Disorder (BDD) and Obsessive-Compulsive Disorder (OCD)
Labuschagne, Izelle, Rossell, Susan, Dunai, Judith, Castle, David and Kyrios, Michael. (2013). A comparison of executive function in Body Dysmorphic Disorder (BDD) and Obsessive-Compulsive Disorder (OCD). Journal of Obsessive-Compulsive and Related Disorders. 2(3), pp. 257 - 262. https://doi.org/10.1016/j.jocrd.2013.05.003
An absolute risk prediction model to determine unplanned cardiovascular readmissions for adults with chronic heart failure
Betihavas, Izelle, Rossell, Susan, Dunai, Judith, Castle, David and Kyrios, Michael. (2013). An absolute risk prediction model to determine unplanned cardiovascular readmissions for adults with chronic heart failure. Heart, Lung and Circulation. 2(3), pp. 257 - 262. https://doi.org/10.1016/j.hlc.2015.04.168
Recognition and referral of depression in patients with heart disease
Worrall-Carter, Linda, Ski, Chantal, Thompson, David, Davidson, Patricia M., Cameron, Janette, Castle, David and Page, Karen Nicola. (2012). Recognition and referral of depression in patients with heart disease. European Journal of Cardiovascular Nursing. 11(2), pp. 231 - 238. https://doi.org/10.1016/j.ejcnurse.2011.04.005
An evaluation of a national program to implement the Cornell Scale for Depression in Dementia into routine practice in aged care facilities
Davison, Tanya, Snowdon, John, Castle, Nathan, McCabe, Marita Patricia, Mellor, David, Karantzas, Gery and Allan, Janelle. (2012). An evaluation of a national program to implement the Cornell Scale for Depression in Dementia into routine practice in aged care facilities. International Psychogeriatrics. 24(4), pp. 631 - 641. https://doi.org/10.1017/S1041610211002146
What the cognitive deficits in body dysmorphic disorder tell us about the underlying neurobiology: An investigation of three cases
Labuschagne, Izelle, Castle, David and Rossell, Susan L.. (2011). What the cognitive deficits in body dysmorphic disorder tell us about the underlying neurobiology: An investigation of three cases. International Journal of Cognitive Therapy. 4(1), pp. 21 - 33. https://doi.org/10.1521/ijct.2011.4.1.21
Executive function in body dysmorphic disorder
Dunai, Judith, Labuschagne, Izelle, Castle, David J., Kyrios, Michael and Rossell, Susan. (2010). Executive function in body dysmorphic disorder. Psychological Medicine. 40(9), pp. 1541 - 1548. https://doi.org/10.1017/S003329170999198X
An examination of delusional thinking and cognitive styles in body dysmorphic disorder
Labuschagne, Izelle, Castle, David J., Dunai, Judith, Kyrios, Michael and Rossell, Susan. (2010). An examination of delusional thinking and cognitive styles in body dysmorphic disorder. Australian and New Zealand Journal of Psychiatry. 44(8), pp. 706 - 712. https://doi.org/10.3109/00048671003671007
A randomized controlled trial of relapse prevention therapy for first-episode psychosis patients
Gleeson, John, Cotton, Sue, Álvarez-Jiménez, Mario, Wade, Darryl, Gee, Donna, Crisp, Kingsley, Pearce, Tracey, Newman, Belinda, Spiliotacopoulos, Daniela, Castle, David J. and McGorry, Patrick. (2009). A randomized controlled trial of relapse prevention therapy for first-episode psychosis patients. Journal of Clinical Psychiatry. 70(4), pp. 477 - 486. https://doi.org/10.4088/JCP.08m04407
The episode ii trial of cognitive and family therapy for relapse prevention in early psychosis: Rationale and sample characteristics
Gleeson, John, Wade, Darryl, Castle, David J., Gee, Donna, Crisp, Kingsley, Pearce, Tracey, Newman, Belinda, Cotton, Sue, Álvarez-Jiménez, Mario, Gilbert, Monica and McGorry, Patrick. (2008). The episode ii trial of cognitive and family therapy for relapse prevention in early psychosis: Rationale and sample characteristics. Journal of Mental Health. 17(1), pp. 19 - 32. https://doi.org/10.1080/09638230701504999