Structural and functional brain correlates of theory of mind impairment post-stroke

Journal article


Duque, Juan F. Dominguez, Nott, Zoie, Horne, Kristina, Prangley, Tarran, Adams, Alexandra G., Henry, Julie D. and Molenberghs, Pascal. (2019) Structural and functional brain correlates of theory of mind impairment post-stroke. Cortex. 121, pp. 427 - 442. https://doi.org/10.1016/j.cortex.2019.09.017
AuthorsDuque, Juan F. Dominguez, Nott, Zoie, Horne, Kristina, Prangley, Tarran, Adams, Alexandra G., Henry, Julie D. and Molenberghs, Pascal
Abstract

The ability to understand the mental states of others – also known as Theory of Mind (ToM) – is critical for normal social interactions. We combine behavioural probes with structural and functional brain imaging to provide the first comprehensive analysis of ToM deficits following stroke using the Reading the Mind in the Eyes Test (RMET). First, fMRI was used to identify the functional brain network involved in a non-clinical cohort. Results indicated that, relative to a control task, the RMET increased activity in a widespread functional bilateral network comprising frontal and temporo-parietal areas. To investigate how damage to grey and white matter components of this network can lead to ToM impairment, parcel-based lesion-symptom mapping (PLSM), white-matter tract-wise statistical analysis (TSA) and disconnectome symptom mapping (DSM) were performed using structural images from 64 stroke patients. PLSM results revealed that low scores on the RMET were associated with damage centered around the right posterior frontal gyrus and insula. TSA and DSM results further revealed that low RMET scores were associated with damage to white-matter tracts connecting frontal and temporo-parietal components of the RMET functional network. Together, these findings suggest that making judgements about the mental states of others imposes demands on a large functional network that can easily be disrupted, both by damage to grey matter areas that form part of the network directly, or the white-matter pathways that connect them.

KeywordsTheory of mind; Lesion symptom mapping; Stroke; Social neuroscience; Reading the mind in the eyes; Social cognition
Year2019
JournalCortex
Journal citation121, pp. 427 - 442
PublisherElsevier BV
ISSN0010-9452
Digital Object Identifier (DOI)https://doi.org/10.1016/j.cortex.2019.09.017
Scopus EID2-s2.0-85074632563
Page range427 - 442
Research GroupMary MacKillop Institute for Health Research
Place of publicationNetherlands
Permalink -

https://acuresearchbank.acu.edu.au/item/86qq5/structural-and-functional-brain-correlates-of-theory-of-mind-impairment-post-stroke

Restricted files

Publisher's version

  • 0
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Episodic foresight deficits in regular, but not recreational, cannabis users
Mercuri, Kimberly, Terrett, Gill, Henry, Julie D., Curran, Elliott, Morgan, Rendell, Peter G. and val.curran@acu.edu.au, H. Valerie Curran. (2018) Episodic foresight deficits in regular, but not recreational, cannabis users. Journal of Psychopharmacology. 32(8), pp. 876 - 882. https://doi.org/10.1177/0269881118776672
Music to my ears: Age-related decline in musical and facial emotion recognition
Sutcliffe, Ryan, Rendell, Peter, Henry, Julie, Bailey, Phoebe and Ruffman, Ted. (2017) Music to my ears: Age-related decline in musical and facial emotion recognition. Psychology and Aging. 32(8), pp. 698 - 709. https://doi.org/10.1037/pag0000203
Prospective memory function and cue salience in mild cognitive impairment: Findings from the Sydney Memory and Ageing Study
Thompson, Claire, Henry, Julie D., Rendell, Peter, Withall, Adrienne, Kochan, Nicole A., Sachdev, Peminder and Brodaty, Henry. (2017) Prospective memory function and cue salience in mild cognitive impairment: Findings from the Sydney Memory and Ageing Study. Journal of Clinical and Experimental Neuropsychology. 39(10), pp. 1 - 13. https://doi.org/10.1080/13803395.2017.1281382
Stereotype threat and social function in opioid substitution therapy patients
von Hippel, Courtney, Henry, Julie D., Terrett, Gill, Mercuri, Kimberly, McAlear, Karen and Rendell, Peter G.. (2017) Stereotype threat and social function in opioid substitution therapy patients. British Journal of Clinical Psychology. 56(2), pp. 160 - 171. https://doi.org/10.1111/bjc.12128
Acting with the future in mind is impaired in long-term opiate users
Terrett, Gill, Lyons, Amanda, Henry, Julie D., Ryrie, Clare, Suddendorf, Thomas and Rendell, Peter G.. (2017) Acting with the future in mind is impaired in long-term opiate users. Psychopharmacology. 234(1), pp. 99 - 108. https://doi.org/10.1007/s00213-016-4442-3
Reduced facial reactivity as a contributor to preserved emotion regulation in older adults
Pedder, David J., Terrett, Gill, Bailey, Phoebe E., Henry, Julie D., Ruffman, Ted and Rendell, Peter G.. (2016) Reduced facial reactivity as a contributor to preserved emotion regulation in older adults. Psychology and Aging. 31(1), pp. 114 - 125. https://doi.org/10.1037/a0039985
The relationship between prospective memory and episodic future thinking in younger and older adulthood
Terrett, Gillian, Rose, Nathan S., Henry, Julie D., Bailey, Phoebe E., Altgassen, Mareike, Phillips, Louise H., Kliegel, Matthias and Rendell, Peter Gregory. (2016) The relationship between prospective memory and episodic future thinking in younger and older adulthood. The Quarterly Journal of Experimental Psychology. 69(2), pp. 310 - 323. https://doi.org/10.1080/17470218.2015.1054294
Deconstructing the nature of episodic foresight deficits associated with chronic opiate use
Mercuri, Kimberly, Terrett, Gill, Bailey, Phoebe E., Henry, Julie D., Curran, Helen Valerie and Rendell, Peter G.. (2016) Deconstructing the nature of episodic foresight deficits associated with chronic opiate use. British Journal of Clinical Psychology. 55(4), pp. 401 - 413. https://doi.org/10.1111/bjc.12110
Episodic foresight and schizophrenia
Lyons, Amanda, Henry, Julie, Rendell, Peter, Robinson, Gail and Suddendorf, Thomas. (2015) Episodic foresight and schizophrenia. British Journal of Clinical Psychology. 1, pp. 1 - 16. https://doi.org/10.1111/bjc.12092
How valid are subjective ratings of prospective memory in mild cognitive impairment and early dementia?
Thompson, Claire, Henry, Julie, Rendell, Peter, Withall, Adrienne and Brodaty, Henry. (2015) How valid are subjective ratings of prospective memory in mild cognitive impairment and early dementia? Gerontology. 61(3), pp. 251 - 257. https://doi.org/10.1159/000371347
Prospective memory function in late adulthood: Affect at encoding and resource allocation costs
Henry, Julie, Joeffry, Sebastian, Terrett, Gill, Ballhausen, Nicola, Kliegel, Matthias and Rendell, Peter. (2015) Prospective memory function in late adulthood: Affect at encoding and resource allocation costs. PLoS One (online). 10(4), pp. 1 - 11. https://doi.org/10.1371/journal.pone.0125124
Towards a better understanding of the relationship between executive control and theory of mind : An intra-cultural comparison of three diverse samples
Shahaeian, Ameneh, Henry, Julie, Razmjoee, Maryam, Teymoori, Ali and Wang, Cen. (2015) Towards a better understanding of the relationship between executive control and theory of mind : An intra-cultural comparison of three diverse samples. Developmental Science (online version). 18(5), pp. 671 - 685. https://doi.org/10.1111/desc.12243
Future thinking improves prospective memory performance and plan enactment in older adults
Altgassen, Mareike, Rendell, Peter, Bernhard, Anka, Henry, Julie, Bailey, Phoebe, Phillips, Louise and Kliegel, Matthias. (2015) Future thinking improves prospective memory performance and plan enactment in older adults. The Quarterly Journal of Experimental Psychology. 68(1), pp. 192 - 204. https://doi.org/10.1080/17470218.2014.956127
Emotional valence differentially affects encoding and retrieval of prospective memory in older adults
Ballhausen, Nicola, Rendell, Peter, Henry, Julie, Joeffry, Sebastian and Kliegel, Matthias. (2015) Emotional valence differentially affects encoding and retrieval of prospective memory in older adults. Aging, Neuropsychology, and Cognition. 22(5), pp. 544 - 559. https://doi.org/10.1080/13825585.2014.1001316
Prospective memory impairment in chronic heart failure
Habota, Tina, McLennan, Skye, Cameron, Jan, Henry, Julie, Ski, Chantal, Thompson, David and Rendell, Peter. (2015) Prospective memory impairment in chronic heart failure. Journal of the International Neuropsychological Society. 21(3), pp. 183 - 192. https://doi.org/10.1017/S1355617715000119
Episodic foresight and aging
Lyons, Amanda, Henry, Julie, Rendell, Peter, Corballis, Michael and Suddendorf, Thomas. (2014) Episodic foresight and aging. Psychology and Aging. 29(4), pp. 873 - 884. https://doi.org/10.1037/a0038130
Examining the time course of young and older adults' mimicry of enjoyment and nonenjoyment smiles
Slessor, Gillian, Bailey, Phoebe, Rendell, Peter, Ruffman, Ted, Henry, Julie and Miles, Lynden. (2014) Examining the time course of young and older adults' mimicry of enjoyment and nonenjoyment smiles. Emotion. 14(3), pp. 532 - 544. https://doi.org/10.1037/a0035825
Prospective memory impairment in long-term opiate users
Terrett, Gillian, McLennan, Skye, Henry, Julie, Biernacki, Kathryn, Mercuri, Kimberly, Curran, Valerie and Rendell, Peter. (2014) Prospective memory impairment in long-term opiate users. Psychopharmacology. 231(13), pp. 2623 - 2632. https://doi.org/10.1007/s00213-014-3432-6
A Virtual Week study of prospective memory function in autism spectrum disorders
Henry, Julie, Terrett, Gillian, Altgassen, Mareike, Raponi-Saunders, Sandra, Ballhausen, Nicola, Schnitzspahn, Katharina and Rendell, Peter. (2014) A Virtual Week study of prospective memory function in autism spectrum disorders. Journal of Experimental Child Psychology. 127, pp. 110 - 125. https://doi.org/10.1016/j.jecp.2014.01.011
Disgust, but not anger provocation, enhances levator labii superioris activity during exposure to moral transgressions
Whitton, Alexis, Henry, Julie, Rendell, Peter and Grisham, Jessica. (2014) Disgust, but not anger provocation, enhances levator labii superioris activity during exposure to moral transgressions. Biological Psychology. 96, pp. 48 - 56. https://doi.org/10.1016/j.biopsycho.2013.11.012
The development of prospective memory in young schoolchildren : The impact of ongoing task absorption, cue salience, and cue centrality
Kliegel, Matthias, Mahy, Caitlin, Voigt, Babett, Henry, Julie, Rendell, Peter and Aberle, Ingo. (2013) The development of prospective memory in young schoolchildren : The impact of ongoing task absorption, cue salience, and cue centrality. Journal of Experimental Child Psychology. https://doi.org/10.1016/j.jecp.2013.07.012
An investigation of prospective memory functions in people with traumatic brain injury using Virtual Week
Mioni, Giovanna, Rendell, Peter, Henry, Julie, Cantagallo, Anna and Stablum, Franca. (2013) An investigation of prospective memory functions in people with traumatic brain injury using Virtual Week. Journal of Clinical and Experimental Neuropsychology. https://doi.org/10.1080/13803395.2013.804036
Episodic future thinking in children with Autism Spectrum Disorder
Terrett, Gillian, Rendell, Peter, Raponi-Saunders, Sandra, Henry, Julie, Bailey, Phoebe and Altgassen, Mareike. (2013) Episodic future thinking in children with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-013-1806-y
Prospective memory, emotional valence and multiple sclerosis
Rendell, Peter, Henry, Julie, Phillips, Louise, De la Piedad Garcia, Xochitl, Booth, Patricia, Phillips, Patricia and Kliegel, Matthias. (2012) Prospective memory, emotional valence and multiple sclerosis. Journal of Clinical and Experimental Neuropsychology. 34(7), pp. 734 - 749. https://doi.org/10.1080/13803395.2012.670388
Perception of biological motion and emotion in mild cognitive impairment and dementia
Henry, Julie, Thompson, Claire, Rendell, Peter, Phillips, Louise, Carbert, Jessica, Sachdev, Peminder and Brodaty, Henry. (2012) Perception of biological motion and emotion in mild cognitive impairment and dementia. Journal of the International Neuropsychological Society. 18(5), pp. 866 - 873. https://doi.org/10.1017/S1355617712000665
Prospective memory reminders : A laboratory investigation of initiation source and age effects
Henry, Julie, Rendell, Peter, Phillips, Louise, Dunlop, Leigh and Kliegel, Matthias. (2012) Prospective memory reminders : A laboratory investigation of initiation source and age effects. Quarterly Journal of Experimental Psychology. 65(7), pp. 1274 - 1287. https://doi.org/10.1080/17470218.2011.651091
Older Adults have greater difficulty imagining future rather than atemporal experiences
Rendell, Peter, Bailey, Phoebe, Henry, Julie, Phillips, Louise, Gaskin, Shae and Kliegel, Matthias. (2012) Older Adults have greater difficulty imagining future rather than atemporal experiences. Psychology and Aging. 27(4), pp. 1089 - 1098. https://doi.org/10.1037/a0029748
Road to full recovery: Longitudinal relationship between symptomatic remission and psychosocial recovery in first-episode psychosis over 7.5 years
Alvarez-Jimenez, Mario, Gleeson, John, Henry, L., Harrigan, Susan, Harris, M., Killackey, Eoin, Bendall, Sarah, Amminger, G., Yung, Alison and Herrman, H.. (2012) Road to full recovery: Longitudinal relationship between symptomatic remission and psychosocial recovery in first-episode psychosis over 7.5 years. Psychological Medicine. 42(3), pp. 595 - 606. https://doi.org/10.1017/S0033291711001504
Prospective memory in schizophrenia and schizotypy
Henry, Julie, Rendell, Peter, Rogers, Phoebe, Altgassen, Mareike and Kliegel, Matthias. (2012) Prospective memory in schizophrenia and schizotypy. Cognitive Neuropsychiatry. 17(2), pp. 133 - 150. https://doi.org/10.1080/13546805.2011.581536
Prospective memory, emotional valence and ageing
Rendell, Peter, Phillips, L., Henry, J., Brumby-Rendell, Tristan, de la Piedad Garcia, Xochitl, Altgassen, M. and Kliegel, M.. (2011) Prospective memory, emotional valence and ageing. Cognition and Emotion (print version). 25(5), pp. 916 - 925. https://doi.org/10.1080/02699931.2010.508610
A naturalistic study of prospective memory function in MCI and dementia
Thompson, C., Henry, J., Withall, A., Rendell, Peter G. and Brodaty, H.. (2011) A naturalistic study of prospective memory function in MCI and dementia. British Journal of Clinical Psychology. 50(4), pp. 425 - 434. https://doi.org/10.1111/j.2044-8260.2010.02004.x
The age-prospective memory-paradox: An exploration of possible mechanisms
Schnitzspahn, K. M., Ihle, A., Henry, J., Rendell, Peter G. and Kliegel, M.. (2011) The age-prospective memory-paradox: An exploration of possible mechanisms. International Psychogeriatrics (print version). 23(4), pp. 583 - 592. https://doi.org/10.1017/S1041610210001651
The influence of emotional target cues on prospective memory performance in depression
Altgassen, Mareike, Henry, Julie, Burgler, S and Kliegel, Matthias. (2011) The influence of emotional target cues on prospective memory performance in depression. Journal of Clinical and Experimental Neuropsychology. 33(8), pp. 910 - 916. https://doi.org/10.1080/13803395.2011.574607
Prospective memory function in mild cognitive impairment and early dementia
Thompson, Claire, Henry, Julie, Rendell, Peter, Withall, Adrienne and Brodaty, Henry. (2010) Prospective memory function in mild cognitive impairment and early dementia. Journal of the International Neuropsychological Society. 16(2), pp. 318 - 325. https://doi.org/10.1017/S1355617709991354
Dismantling the age-prospective memory paradox: The classic laboratory paradigm simulated in a naturalistic setting
Bailey, Phoebe, Henry, Julie, Rendell, Peter, Phillips, Louise H. and Kliegel, Matthias. (2010) Dismantling the age-prospective memory paradox: The classic laboratory paradigm simulated in a naturalistic setting. Quarterly Journal of Experimental Psychology. 63(4), pp. 646 - 652. https://doi.org/10.1080/17470210903521797
Threat perception in schizophrenia-spectrum disorders
Henry, Julie, Hippel, Courtney von, Ruffman, Ted, Perry, Yael and Rendell, Peter. (2010) Threat perception in schizophrenia-spectrum disorders. Journal of the International Neuropsychological Society. 16(5), pp. 805 - 812. https://doi.org/10.1017/S1355617710000640
Emotional target cues eliminate age differences in prospective memory
Altgassen, Mareike, Phillips, Louise H., Henry, Julie, Rendell, Peter and Kliegel, Matthias. (2010) Emotional target cues eliminate age differences in prospective memory. Quarterly Journal of Experimental Psychology. 63(6), pp. 1057 - 1064. https://doi.org/10.1080/17470211003770920
Alexithymia in schizophrenia
Henry, Julie, Bailey, Phoebe, von Hippel, Courtney, Rendell, Peter and Lane, Adam. (2010) Alexithymia in schizophrenia. Journal of Clinical and Experimental Neuropsychology. 32(8), pp. 890 - 897. https://doi.org/10.1080/13803391003596462
Cognitively impaired older adults exhibit comparable difficulties on naturalistic and laboratory prospective memory tasks
Will, Christine M., Rendell, Peter Gregory, Ozgis, Sesil, Pierson, Jane M., Ong, Ben and Henry, Julie D.. (2009) Cognitively impaired older adults exhibit comparable difficulties on naturalistic and laboratory prospective memory tasks. Applied Cognitive Psychology. 23(6), pp. 804 - 812. https://doi.org/10.1002/acp.1514
Emotion dysregulation and schizotypy
Henry, Julie D., Green, Melissa J., Restuccia, Corinne, de Lucia, Amber, Rendell, Peter Gregory, McDonald, Skye and Grisham, Jessica R.. (2009) Emotion dysregulation and schizotypy. Psychiatry Research. 166(2-3), pp. 116 - 124. https://doi.org/10.1016/j.psychres.2008.01.007
Social-cognitive difficulties in former users of methamphetamine
Henry, Julie D., Mazur, Magdalena and Rendell, Peter Gregory. (2009) Social-cognitive difficulties in former users of methamphetamine. British Journal of Clinical Psychology. 48(3), pp. 323 - 327. https://doi.org/10.1111/j.2044-8260.2009.tb00487.x
A review of virtual week for prospective memory assessment: Clinical implications
Rendell, Peter Gregory and Henry, Julie. (2009) A review of virtual week for prospective memory assessment: Clinical implications. Brain Impairment. 10(1), pp. 14 - 22. https://doi.org/10.1375/brim.10.1.14
Prospective memory impairment in former users of methamphetamine
Rendell, Peter Gregory, Mazur, Magdalena and Henry, Julie D.. (2009) Prospective memory impairment in former users of methamphetamine. Psychopharmacology. 230(3), pp. 609 - 616. https://doi.org/10.1007/s00213-008-1408-0
Emotion experience, expression, and regulation in alzheimer's disease
Henry, Julie D., Rendell, Peter Gregory, Scicluna, Amanda Christine, Jackson, Michelle Louise and Phillips, Louise H.. (2009) Emotion experience, expression, and regulation in alzheimer's disease. Psychology and Aging. 24(1), pp. 252 - 257. https://doi.org/10.1037/a0014001
Evidence for deficits in facial affect recognition and theory of mind in multiple sclerosis
Henry, Julie D., Phillips, Louise H., Beatty, William W., McDonald, Skye, Longley, Wendy A., Joscelyne, Amy and Rendell, Peter. (2009) Evidence for deficits in facial affect recognition and theory of mind in multiple sclerosis. Journal of the International Neuropsychological Society. 15(2), pp. 277 - 285. https://doi.org/10.1017/S1355617709090195
Spaced retrieval significantly improves prospective memory performance of cognitively impaired older adults
Ozgis, Sesil, Rendell, Peter Gregory and Henry, Julie D.. (2009) Spaced retrieval significantly improves prospective memory performance of cognitively impaired older adults. Gerontology. 55(2), pp. 229 - 232. https://doi.org/10.1159/000163446
Emotion regulation in schizophrenia: Affective, social and clinical correlates of suppression and reappraisal
Henry, Julie, Rendell, Peter, Green, Melissa, McDonald, Skye and O'Donnell, Maryanne. (2008) Emotion regulation in schizophrenia: Affective, social and clinical correlates of suppression and reappraisal. Journal of Abnormal Psychology. 117(2), pp. 473 - 478. https://doi.org/10.1037/0021-843X.117.2.473
Recognition of disgust is selectively preserved in alzheimer's disease
Henry, Julie, Ruffman, Ted, McDonald, Skye, Peek-O'Leary, Marie-Andree, Phillips, Louise H., Brodaty, Henry and Rendell, Peter. (2008) Recognition of disgust is selectively preserved in alzheimer's disease. Neuropsychologia. 46(5), pp. 1363 - 1370. https://doi.org/10.1016/j.neuropsychologia.2007.12.012
Empathy, social functioning and schizotypy
Henry, Julie, Bailey, Phoebe and Rendell, Peter. (2008) Empathy, social functioning and schizotypy. Psychiatry Research. 160(1), pp. 15 - 22. https://doi.org/10.1016/j.psychres.2007.04.014
Prospective memory in schizophrenia: The impact of varying retrospective-memory load
Altgassen, Mareike, Kliegel, Matthias, Rendell, Peter, Henry, Julie and Zöllig, Jacqueline. (2008) Prospective memory in schizophrenia: The impact of varying retrospective-memory load. Journal of Clinical and Experimental Neuropsychology. 30(7), pp. 777 - 788. https://doi.org/10.1080/13803390701779552
Prospective-memory functioning is affected during pregnancy and postpartum
Rendell, Peter and Henry, Julie. (2008) Prospective-memory functioning is affected during pregnancy and postpartum. Journal of Clinical and Experimental Neuropsychology. 30(8), pp. 913 - 919. https://doi.org/10.1080/13803390701874379
Prospective memory in multiple sclerosis
Rendell, Peter, Jensen, Fiona and Henry, Julie. (2007) Prospective memory in multiple sclerosis. Journal of the International Neuropsychological Society. 13(3), pp. 410 - 416. https://doi.org/10.1017/S1355617707070579
A review of the impact of pregnancy on memory function
Henry, Julie and Rendell, Peter. (2007) A review of the impact of pregnancy on memory function. Journal of Clinical and Experimental Neuropsychology. 29(8), pp. 793 - 803. https://doi.org/10.1080/13803390701612209
Prospective memory impairment in "ecstasy" (MDMA) users
Rendell, Peter G., Gray, Timothy J., Henry, Julie D. and Tolan, Georgina Anne. (2007) Prospective memory impairment in "ecstasy" (MDMA) users. Psychopharmacology. 194(4), pp. 497 - 504. https://doi.org/10.1007/s00213-007-0859-z
Prospective memory in schizophrenia: Primary or secondary impairment?
Henry, Julie, Rendell, Peter, Kliegel, Matthias and Altgassen, Mareike. (2007) Prospective memory in schizophrenia: Primary or secondary impairment? Schizophrenia Research. 95(March), pp. 179 - 185. https://doi.org/10.1016/j.schres.2007.06.003