Short and long term effects of left and bilateral repetitive transcranial magnetic stimulation in schizophrenia patients with auditory verbal hallucinations: A randomized controlled trial

Journal article


Bais, Leonie, Vercammen, Ans, Stewart, Roy, van Es, Frank, Visser, Bert, Aleman, Andre and Knegtering, Henderikus. (2014). Short and long term effects of left and bilateral repetitive transcranial magnetic stimulation in schizophrenia patients with auditory verbal hallucinations: A randomized controlled trial. PLoS ONE. 9(10), pp. 1 - 10. https://doi.org/10.1371/journal.pone.0108828
AuthorsBais, Leonie, Vercammen, Ans, Stewart, Roy, van Es, Frank, Visser, Bert, Aleman, Andre and Knegtering, Henderikus
Abstract

Background Repetitive transcranial magnetic stimulation of the left temporo-parietal junction area has been studied as a treatment option for auditory verbal hallucinations. Although the right temporo-parietal junction area has also shown involvement in the genesis of auditory verbal hallucinations, no studies have used bilateral stimulation. Moreover, little is known about durability effects. We studied the short and long term effects of 1 Hz treatment of the left temporo-parietal junction area in schizophrenia patients with persistent auditory verbal hallucinations, compared to sham stimulation, and added an extra treatment arm of bilateral TPJ area stimulation.

Methods In this randomized controlled trial, 51 patients diagnosed with schizophrenia and persistent auditory verbal hallucinations were randomly allocated to treatment of the left or bilateral temporo-parietal junction area or sham treatment. Patients were treated for six days, twice daily for 20 minutes. Short term efficacy was measured with the Positive and Negative Syndrome Scale (PANSS), the Auditory Hallucinations Rating Scale (AHRS), and the Positive and Negative Affect Scale (PANAS). We included follow-up measures with the AHRS and PANAS at four weeks and three months.

Results The interaction between time and treatment for Hallucination item P3 of the PANSS showed a trend for significance, caused by a small reduction of scores in the left group. Although self-reported hallucination scores, as measured with the AHRS and PANAS, decreased significantly during the trial period, there were no differences between the three treatment groups.

Conclusion We did not find convincing evidence for the efficacy of left-sided rTMS, compared to sham rTMS. Moreover, bilateral rTMS was not superior over left rTMS or sham in improving AVH. Optimizing treatment parameters may result in stronger evidence for the efficacy of rTMS treatment of AVH. Moreover, future research should consider investigating factors predicting individual response.

Year2014
JournalPLoS ONE
Journal citation9 (10), pp. 1 - 10
ISSN1932-6203
Digital Object Identifier (DOI)https://doi.org/10.1371/journal.pone.0108828
Scopus EID2-s2.0-84908208930
Open accessOpen access
Page range1 - 10
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© 2014 Bais et al. This is an open-access article distributed under the terms of the [http://creativecommons.org/licenses/by/4.0/] Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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