Short and long term effects of left and bilateral repetitive transcranial magnetic stimulation in schizophrenia patients with auditory verbal hallucinations: A randomized controlled trial

Journal article


Bais, Leonie, Vercammen, Ans, Stewart, Roy, van Es, Frank, Visser, Bert, Aleman, Andre and Knegtering, Henderikus. (2014). Short and long term effects of left and bilateral repetitive transcranial magnetic stimulation in schizophrenia patients with auditory verbal hallucinations: A randomized controlled trial. PLoS ONE. 9(10), pp. 1 - 10. https://doi.org/10.1371/journal.pone.0108828
AuthorsBais, Leonie, Vercammen, Ans, Stewart, Roy, van Es, Frank, Visser, Bert, Aleman, Andre and Knegtering, Henderikus
Abstract

Background Repetitive transcranial magnetic stimulation of the left temporo-parietal junction area has been studied as a treatment option for auditory verbal hallucinations. Although the right temporo-parietal junction area has also shown involvement in the genesis of auditory verbal hallucinations, no studies have used bilateral stimulation. Moreover, little is known about durability effects. We studied the short and long term effects of 1 Hz treatment of the left temporo-parietal junction area in schizophrenia patients with persistent auditory verbal hallucinations, compared to sham stimulation, and added an extra treatment arm of bilateral TPJ area stimulation.

Methods In this randomized controlled trial, 51 patients diagnosed with schizophrenia and persistent auditory verbal hallucinations were randomly allocated to treatment of the left or bilateral temporo-parietal junction area or sham treatment. Patients were treated for six days, twice daily for 20 minutes. Short term efficacy was measured with the Positive and Negative Syndrome Scale (PANSS), the Auditory Hallucinations Rating Scale (AHRS), and the Positive and Negative Affect Scale (PANAS). We included follow-up measures with the AHRS and PANAS at four weeks and three months.

Results The interaction between time and treatment for Hallucination item P3 of the PANSS showed a trend for significance, caused by a small reduction of scores in the left group. Although self-reported hallucination scores, as measured with the AHRS and PANAS, decreased significantly during the trial period, there were no differences between the three treatment groups.

Conclusion We did not find convincing evidence for the efficacy of left-sided rTMS, compared to sham rTMS. Moreover, bilateral rTMS was not superior over left rTMS or sham in improving AVH. Optimizing treatment parameters may result in stronger evidence for the efficacy of rTMS treatment of AVH. Moreover, future research should consider investigating factors predicting individual response.

Year2014
JournalPLoS ONE
Journal citation9 (10), pp. 1 - 10
ISSN1932-6203
Digital Object Identifier (DOI)https://doi.org/10.1371/journal.pone.0108828
Scopus EID2-s2.0-84908208930
Open accessOpen access
Page range1 - 10
Publisher's version
License
Additional information

© 2014 Bais et al. This is an open-access article distributed under the terms of the [http://creativecommons.org/licenses/by/4.0/] Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Permalink -

https://acuresearchbank.acu.edu.au/item/8836v/short-and-long-term-effects-of-left-and-bilateral-repetitive-transcranial-magnetic-stimulation-in-schizophrenia-patients-with-auditory-verbal-hallucinations-a-randomized-controlled-trial

Download files


Publisher's version
  • 76
    total views
  • 93
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Adjunctive selective estrogen receptor modulator increases neural activity in the hippocampus and inferior frontal gyrus during emotional face recognition in schizophrenia
Ji, Ellen, Weickert, Cynthia S., Lenroot, Rhoshel, Kindler, J., Skilleter, Ashley J., Vercammen, Ans, White, Christopher, Gur, R. E. and Weickert, Thomas W.. (2016). Adjunctive selective estrogen receptor modulator increases neural activity in the hippocampus and inferior frontal gyrus during emotional face recognition in schizophrenia. Translational Psychiatry. 6, pp. 1 - 9. https://doi.org/10.1038/tp.2016.59
Anodal tDCS targeting the right orbitofrontal cortex enhances facial expression recognition
Willis, Megan L., Murphy, Jillian M., Ridley, Nicole J. and Vercammen, Ans. (2015). Anodal tDCS targeting the right orbitofrontal cortex enhances facial expression recognition. Social Cognitive and Affective Neuroscience. 10(12), pp. 1677 - 1683. https://doi.org/10.1093/scan/nsv057
Common polymorphisms in dopamine-related genes combine to produce a 'schizophrenia-like' prefrontal hypoactivity
Vercammen, Ans, Weickert, Cynthia, Skilleter, Ashley, Lenroot, Rhoshel, Schofield, Peter and Weickert, Thomas. (2014). Common polymorphisms in dopamine-related genes combine to produce a 'schizophrenia-like' prefrontal hypoactivity. Translational Psychiatry. 4(2), pp. 1 - 7. https://doi.org/10.1038/tp.2013.125
Testosterone is inversely related to brain activity during emotional inhibition in schizophrenia
Vercammen, Ans, Skilleter, Ashley, Lenroot, Rhoshel, Catts, Stanley, Weickert, Cynthia and Weickert, Thomas. (2013). Testosterone is inversely related to brain activity during emotional inhibition in schizophrenia. PLoS ONE. 8(10), pp. 1 - 10. https://doi.org/10.1371/journal.pone.0077496
Serum testosterone levels are related to cognitive function in men with schizophrenia
Moore, Loretta, Kyaw, Merribel, Vercammen, Ans, Lenroot, Rhoshel, Kulkarni, Jayashri, Curtis, Jackie, O'Donnell, Maryanne, Carr, Vaughn, Weickert, Cynthia and Weickert, Thomas. (2013). Serum testosterone levels are related to cognitive function in men with schizophrenia. Psychoneuroendocrinology. https://doi.org/10.1016/j.psyneuen.2013.02.007
When Broca goes uninformed : reduced information flow to Broca's area in Schizophrenia patients with auditory hallucinations
Curcic-Blake, Branislava, Liemburg, Edith, Vercammen, Ans, Swart, Marte, Knegtering, Henderikus, Bruggeman, Richard and Aleman, Andre. (2013). When Broca goes uninformed : reduced information flow to Broca's area in Schizophrenia patients with auditory hallucinations. Schizophrenia Bulletin. https://doi.org/10.1093/schbul/sbs107
Serum testosterone levels are related to cognitive function in men with schizophrenia
Moore, Loretta, Kyaw, Merribel, Vercammen, Ans, Lenroot, Rhoshel, Kulkarni, Jayashri, Curtis, Jackie, O'Donnell, Maryanne, Carr, Vaughn, Weickert, Cynthia and Weickert, Thomas. (2013). Serum testosterone levels are related to cognitive function in men with schizophrenia. Psychoneuroendocrinology. https://doi.org/10.1016/j.psyneuen.2013.02.007
Testosterone is inversely related to brain activity during emotional inhibition in schizophrenia
Vercammen, Ans, Skilleter, Ashley, Lenroot, Rhoshel, Catts, Stanley, Weickert, Cynthia and Weickert, Thomas. (2013). Testosterone is inversely related to brain activity during emotional inhibition in schizophrenia. PLoS ONE. 8(10), pp. 1 - 10. https://doi.org/10.1371/journal.pone.0077496
When Broca goes uninformed : reduced information flow to Broca's area in Schizophrenia patients with auditory hallucinations
Curcic-Blake, Branislava, Liemburg, Edith, Vercammen, Ans, Swart, Marte, Knegtering, Henderikus, Bruggeman, Richard and Aleman, Andre. (2013). When Broca goes uninformed : reduced information flow to Broca's area in Schizophrenia patients with auditory hallucinations. Schizophrenia Bulletin. https://doi.org/10.1093/schbul/sbs107
Rethinking schizophrenia in the context of normal neurodevelopment
Catts, Vibeke, Fung, Samantha, Long, Leonora, Joshi, Dipesh, Vercammen, Ans, Katherine, Allen, Fillman, Stu, Rothmond, Debora, Sinclair, Duncan and Tiwari, Yash. (2013). Rethinking schizophrenia in the context of normal neurodevelopment. Frontiers in Cellular Neuroscience. https://doi.org/10.3389/fncel.2013.00060
Abnormal connectivity between attentional, language and auditory networks in schizophrenia
Liemburg, Edith, Vercammen, Ans, Horst, Gert-Jan, Curcic-Blake, Branislava, Knegtering, Henderikus and Aleman, Andre. (2012). Abnormal connectivity between attentional, language and auditory networks in schizophrenia. Schizophrenia Research. 135(2016-03-01), pp. 15 - 22. https://doi.org/10.1016/j.schres.2011.12.003
Disambiguating ventral striatum fMRI-related BOLD signal during reward prediction in schizophrenia
Morris, Richard, Vercammen, Ans, Lenroot, Rhoshel, Moore, Loretta, Langton, Julia, Short, Brooke, Kulkarni, Jayashri, Curtis, Jackie, O'Donnell, Maryanne and Weickert, Cynthia. (2012). Disambiguating ventral striatum fMRI-related BOLD signal during reward prediction in schizophrenia. Molecular Psychiatry. 17(3), pp. 280 - 289. https://doi.org/10.1038/mp.2011.75
Disambiguating ventral striatum fMRI-related BOLD signal during reward prediction in schizophrenia
Morris, Richard, Vercammen, Ans, Lenroot, Rhoshel, Moore, Loretta, Langton, Julia, Short, Brooke, Kulkarni, Jayashri, Curtis, Jackie, O'Donnell, Maryanne and Weickert, Cynthia. (2012). Disambiguating ventral striatum fMRI-related BOLD signal during reward prediction in schizophrenia. Molecular Psychiatry. 17(3), pp. 280 - 289. https://doi.org/10.1038/mp.2011.75
Functional neuroimaging of hallucinations
Aleman, Andre and Vercammen, Ans. (2012). Functional neuroimaging of hallucinations. In In I. Sommer and J. D. Blom (Ed.). Hallucinations: Research and Practice pp. 267 - 281 Springer.
The "bottom-up" and "top-down" components of the hallucinatory phenomenon
Aleman, Andre and Vercammen, Ans. (2012). The "bottom-up" and "top-down" components of the hallucinatory phenomenon. In In R. Jardri, A. Cachia and P. Thomas (Ed.). The Neuroscience of Hallucinations pp. 107 - 121 Springer.
Reduced neural activity of the prefrontal cognitive control circuitry during response inhibition to negative words in people with schizophrenia
Vercammen, Ans, Morris, Richard, Green, Melissa, Lenroot, Rhoshel, Kulkarni, Jayashri, Carr, Vaughn, Weickert, Cynthia and Weickert, Thomas. (2012). Reduced neural activity of the prefrontal cognitive control circuitry during response inhibition to negative words in people with schizophrenia. Journal of Psychiatry and Neuroscience. 37(6), pp. 379 - 388. https://doi.org/10.1503/jpn.110088
Reduced neural activity of the prefrontal cognitive control circuitry during response inhibition to negative words in people with schizophrenia
Vercammen, Ans, Morris, Richard, Green, Melissa, Lenroot, Rhoshel, Kulkarni, Jayashri, Carr, Vaughn, Weickert, Cynthia and Weickert, Thomas. (2012). Reduced neural activity of the prefrontal cognitive control circuitry during response inhibition to negative words in people with schizophrenia. Journal of Psychiatry and Neuroscience. 37(6), pp. 379 - 388. https://doi.org/10.1503/jpn.110088
Abnormal connectivity between attentional, language and auditory networks in schizophrenia
Liemburg, Edith, Vercammen, Ans, Horst, Gert-Jan, Curcic-Blake, Branislava, Knegtering, Henderikus and Aleman, Andre. (2012). Abnormal connectivity between attentional, language and auditory networks in schizophrenia. Schizophrenia Research. 135(1-3), pp. 15 - 22. https://doi.org/10.1016/j.schres.2011.12.003
Subjective loudness and reality of auditory verbal hallucinations and activation of the inner speech processing network
Vercammen, Ans, Knegtering, Henderikus, Bruggeman, Richard and Aleman, Andre. (2011). Subjective loudness and reality of auditory verbal hallucinations and activation of the inner speech processing network. Schizophrenia Bulletin. 37(5), pp. 1009 - 1016. https://doi.org/10.1093/schbul/sbq007
Transcranial direct current stimulation influences probabilistic association learning in schizophrenia
Vercammen, Ans, Rushby, Jacqueline, Loo, Colleen, Short, Brooke, Weickert, Cynthia and Weickert, Thomas. (2011). Transcranial direct current stimulation influences probabilistic association learning in schizophrenia. Schizophrenia Research. 131(1-3), pp. 198 - 205. https://doi.org/10.1016/j.schres.2011.06.021
Frontal and parietal contributions to probabilistic association learning
Rushby, Jacqueline, Vercammen, Ans, Loo, Colleen, Short, Brooke, Weickert, Cynthia and Weickert, Thomas. (2011). Frontal and parietal contributions to probabilistic association learning. Cerebral Cortex. 21(8), pp. 1879 - 1888. https://doi.org/10.1093/cercor/bhq255
Semantic expectations can induce false perceptions in hallucination-prone individuals
Vercammen, Ans and Aleman, Andre. (2010). Semantic expectations can induce false perceptions in hallucination-prone individuals. Schizophrenia Bulletin. 36(1), pp. 151 - 156. https://doi.org/10.1093/schbul/sbn063
Functional connectivity of the temporo-parietal region in schizophrenia : effects of rTMS treatment of auditory hallucinations
Vercammen, Ans, Knegtering, Henderikus, Liemburg, Edith, den Boer, Hans and Aleman, Andre. (2010). Functional connectivity of the temporo-parietal region in schizophrenia : effects of rTMS treatment of auditory hallucinations. Journal of Psychiatric Research. 44(11), pp. 725 - 731. https://doi.org/10.1016/j.jpsychires.2009.12.011
Functional connectivity of the temporo-parietal region in schizophrenia : effects of rTMS treatment of auditory hallucinations
Vercammen, Ans, Knegtering, Henderikus, Liemburg, Edith, den Boer, Hans and Aleman, Andre. (2010). Functional connectivity of the temporo-parietal region in schizophrenia : effects of rTMS treatment of auditory hallucinations. Journal of Psychiatric Research. 44(11), pp. 725 - 731. https://doi.org/10.1016/j.jpsychires.2009.12.011
Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the temporo-parietal area
Vercammen, Ans, Knegtering, Henderikus, den Boer, Hans, Liemburg, Edith and Aleman, Andre. (2010). Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the temporo-parietal area. Biological Psychiatry. 67(10), pp. 912 - 918. https://doi.org/10.1016/j.biopsych.2009.11.017
Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the temporo-parietal area
Vercammen, Ans, Knegtering, Henderikus, den Boer, Hans, Liemburg, Edith and Aleman, Andre. (2010). Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the temporo-parietal area. Biological Psychiatry. 67(10), pp. 912 - 918. https://doi.org/10.1016/j.biopsych.2009.11.017
Semantic expectations can induce false perceptions in hallucination-prone individuals
Vercammen, Ans and Aleman, Andre. (2010). Semantic expectations can induce false perceptions in hallucination-prone individuals. Schizophrenia Bulletin. 36(1), pp. 151 - 156.
Effects of bilateral repetitive transcranial magnetic stimulation on treatment resistant auditory-verbal hallucinations in schizophrenia: a randomized controlled trial
Vercammen, Ans, Knegtering, Henderikus, Bruggeman, Richard, Westenbroek, Hanneke M., Jenner, Jack A., Slooff, Cees J., Wunderink, Lex and Aleman, Andre. (2009). Effects of bilateral repetitive transcranial magnetic stimulation on treatment resistant auditory-verbal hallucinations in schizophrenia: a randomized controlled trial. Schizophrenia Research. 114(1-3), pp. 172 - 179. https://doi.org/10.1016/j.schres.2009.07.013
Conceptual and physical object qualities contribute differently to motor affordances
Vingerhoets, Guy, Vandamme, Kim and Vercammen, Ans. (2009). Conceptual and physical object qualities contribute differently to motor affordances. Brain and Cognition. 69(3), pp. 481 - 489. https://doi.org/10.1016/j.bandc.2008.10.003
Structural covariance in the hallucinating brain: A voxel-based morphometry study
Modinos, Gemma, Vercammen, Ans, Mechelli, Andrea, Knegtering, Henderikus, McGuire, Paul K.W. and Aleman, Andre. (2009). Structural covariance in the hallucinating brain: A voxel-based morphometry study. Journal of Psychiatry and Neuroscience. 34(6), pp. 465 - 469.
Hearing a voice in the noise: Auditory hallucinations and speech perception
Vercammen, Ans, de Haan, Edward H.F. and Aleman, Andre. (2008). Hearing a voice in the noise: Auditory hallucinations and speech perception. Psychological Medicine. 38(8), pp. 1177 - 1184. https://doi.org/10.1017/S0033291707002437