Increased physical activity post-exacerbation is associated with decreased systemic inflammation in cystic fibrosis: An observational study
Journal article
Burton, Kate, Morris, Norman R., Reid, David, Smith, Daniel and Kuys, Suzanne. (2020). Increased physical activity post-exacerbation is associated with decreased systemic inflammation in cystic fibrosis: An observational study. Physiotherapy Theory and Practice. 36(12), pp. 1457-1465. https://doi.org/10.1080/09593985.2019.1566942
Authors | Burton, Kate, Morris, Norman R., Reid, David, Smith, Daniel and Kuys, Suzanne |
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Abstract | Background and Objective: We assessed whether measured physical activity in adults with cystic fibrosis (CF) following in-hospital treatment for an acute exacerbation was impacted by levels of systemic and airway inflammation, and whether physical activity post-discharge predicted for time to next pulmonary exacerbation. Methods: Adults with CF were included following hospitalization for a pulmonary exacerbation, and were followed for 12 months. Inflammatory markers and physical activity were measured immediately post-discharge via sputum and plasma concentrations of interleukin-6, interleukin-8, and tumor necrosis factor-α. Physical activity was monitored for 7 days via a Sensewear Armband. Statistical analyses included Shapiro-Wilk’s test and Q–Q plots to determine normal distribution, t-tests, Pearson’s correlational analyses, and one-way MANOVAs. Results: Thirty-one adults with CF (13 females, 28.8 ± 8.8 years, forced expiratory volume in 1 s (FEV1) 59.4 ± 23.0% predicted) were prospectively recruited. Physical activity negatively correlated with plasma inflammation (r = −0.48, p < 0.01), and positively with FEV1 (r = 0.45, p < 0.05) and body mass index (r = 0.39, p < 0.05). There was no significant relationship between time to re-exacerbation and any inflammatory markers or measurement of physical activity (all p > 0.05). Conclusion: Increased physical activity following exacerbation in CF is associated with lower levels of systemic inflammation. Time to re-exacerbation is not related to post-discharge inflammation or physical activity levels. |
Keywords | adults; cystic fibrosis; cytokines; inflammation; physical activity |
Year | 2020 |
Journal | Physiotherapy Theory and Practice |
Journal citation | 36 (12), pp. 1457-1465 |
Publisher | Taylor & Francis |
ISSN | 0959-3985 |
Digital Object Identifier (DOI) | https://doi.org/10.1080/09593985.2019.1566942 |
Scopus EID | 2-s2.0-85060929119 |
Research or scholarly | Research |
Page range | 1457-1465 |
Research Group | School of Allied Health |
Publisher's version | File Access Level Controlled |
Output status | Published |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/8q627/increased-physical-activity-post-exacerbation-is-associated-with-decreased-systemic-inflammation-in-cystic-fibrosis-an-observational-study
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