Dietary patterns and β-amyloid deposition in aging Australian women

Journal article


Hill, Edward, Clifton, Peter, Goodwill, Alicia M., Dennerstein, Lorraine, Campbell, Stephen and Szoeke, Cassandra. (2018). Dietary patterns and β-amyloid deposition in aging Australian women. Alzheimer's and Dementia: Translational Research and Clinical Interventions. 4(1), pp. 535-541. https://doi.org/10.1016/j.trci.2018.09.007
AuthorsHill, Edward, Clifton, Peter, Goodwill, Alicia M., Dennerstein, Lorraine, Campbell, Stephen and Szoeke, Cassandra
Abstract

Introduction
Evidence indicates that associations between diet and Alzheimer's disease may occur through biomarker pathways such as amyloid‐β (Aβ); however, few studies have investigated dietary/Aβ relationships, and no study has investigated this relationship in women.

Methods
Dietary patterns were extrapolated for 115 participants from the Women's Health Aging Project. Aβ deposition was measured via in vivo F‐18 florbetaben positron emission tomography scanning.

Results
Participants were, on average, aged 70 years (±2.63 SD), had 13 years of education (±3.57 SD), a BMI of 28 kg/m2 (±5.46 SD), and a daily energy intake of 5161 kJ (±1679.03 SD). Four dietary patterns were identified: high fat, Mediterranean, junk food, and low fat. Adherence to the junk food diet was a significant predictor of Aβ deposition (β = .10, P = .03).

Discussion
This study highlights the potential of diet to influence neurodegenerative disease and as a potential modifiable lifestyle risk factor for Alzheimer's disease.

Keywordsbiomarkers; Alzheimer’s disease; neuropathology; b-amyloid protein; diet; nutrition; dietary pattern; factor analysis; women
Year2018
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Journal citation4 (1), pp. 535-541
PublisherElsevier Inc.
ISSN2352-8737
Digital Object Identifier (DOI)https://doi.org/10.1016/j.trci.2018.09.007
Scopus EID2-s2.0-85055501357
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range535-541
FunderNational Health and Medical Research Council (NHMRC)
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online13 Oct 2018
Publication process dates
Deposited14 May 2021
Grant IDNHMRC/547600
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