Dietary patterns and β-amyloid deposition in aging Australian women

Journal article

Hill, Edward, Clifton, Peter, Goodwill, Alicia M., Dennerstein, Lorraine, Campbell, Stephen and Szoeke, Cassandra. (2018). Dietary patterns and β-amyloid deposition in aging Australian women. Alzheimer's and Dementia: Translational Research and Clinical Interventions. 4(1), pp. 535-541. https://doi.org/10.1016/j.trci.2018.09.007
AuthorsHill, Edward, Clifton, Peter, Goodwill, Alicia M., Dennerstein, Lorraine, Campbell, Stephen and Szoeke, Cassandra
Abstract

Introduction
Evidence indicates that associations between diet and Alzheimer's disease may occur through biomarker pathways such as amyloid‐β (Aβ); however, few studies have investigated dietary/Aβ relationships, and no study has investigated this relationship in women.

Methods
Dietary patterns were extrapolated for 115 participants from the Women's Health Aging Project. Aβ deposition was measured via in vivo F‐18 florbetaben positron emission tomography scanning.

Results
Participants were, on average, aged 70 years (±2.63 SD), had 13 years of education (±3.57 SD), a BMI of 28 kg/m2 (±5.46 SD), and a daily energy intake of 5161 kJ (±1679.03 SD). Four dietary patterns were identified: high fat, Mediterranean, junk food, and low fat. Adherence to the junk food diet was a significant predictor of Aβ deposition (β = .10, P = .03).

Discussion
This study highlights the potential of diet to influence neurodegenerative disease and as a potential modifiable lifestyle risk factor for Alzheimer's disease.

Keywordsbiomarkers; Alzheimer’s disease; neuropathology; b-amyloid protein; diet; nutrition; dietary pattern; factor analysis; women
Year2018
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Journal citation4 (1), pp. 535-541
PublisherElsevier Inc.
ISSN2352-8737
Digital Object Identifier (DOI)https://doi.org/10.1016/j.trci.2018.09.007
Scopus EID2-s2.0-85055501357
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range535-541
FunderNational Health and Medical Research Council (NHMRC)
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online13 Oct 2018
Publication process dates
Deposited14 May 2021
Grant IDNHMRC/547600
Permalink -

https://acuresearchbank.acu.edu.au/item/8w0x3/dietary-patterns-and-amyloid-deposition-in-aging-australian-women

Log in to edit

Download files

Publisher's version
OA_Edward_2018_Dietary_patterns_and_β_amyloid_deposition.pdf
License: CC BY-NC-ND 4.0
File access level: Open

  • 96
    total views
  • 39
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Energy and macronutrient intakes at breakfast and cognitive declines in community-dwelling older adults : A 9-year follow-up cohort study
Xianwen Shang, Hill, Edward, Li, Yanping and He, Mingguang. (2021). Energy and macronutrient intakes at breakfast and cognitive declines in community-dwelling older adults : A 9-year follow-up cohort study. American Journal of Clinical Nutrition. 113(5), pp. 1093-1103. https://doi.org/10.1093/ajcn/nqaa403
Incidence, progression, and patterns of multimorbidity in community-dwelling middle-aged men and women
Shang, Xianwen, Peng, Wei, Hill, Hill, Szoeke, Cassandra, He, Mingguang and Zhang, Lei. (2020). Incidence, progression, and patterns of multimorbidity in community-dwelling middle-aged men and women. Frontiers in Public Health. 8(404), pp. 1-12. https://doi.org/10.3389/fpubh.2020.00404
Preventive potential of diet in the pre-clinical phase of Alzheimer’s disease symptomatology
Hill, Edward. (2020). Preventive potential of diet in the pre-clinical phase of Alzheimer’s disease symptomatology [Thesis]. https://doi.org/10.26199/j4sr-5317
Incidence of medication-treated depression and anxiety associated with long-term cancer, cardiovascular disease, diabetes and osteoarthritis in community-dwelling women and men
Shang, Xianwen, Peng, Wei, Hill, Edward, Szoeke, Cassandra, He, Mingguang and Zhang, Lei. (2019). Incidence of medication-treated depression and anxiety associated with long-term cancer, cardiovascular disease, diabetes and osteoarthritis in community-dwelling women and men. EClinicalMedicine. 15, pp. 23-32. https://doi.org/10.1016/j.eclinm.2019.08.010
Diet and biomarkers of Alzheimer's disease : A systematic review and meta-analysis
Hill, Edward, Goodwill, Alicia M., Gorelik, Alexandra and Szoeke, Cassandra. (2019). Diet and biomarkers of Alzheimer's disease : A systematic review and meta-analysis. Neurobiology of Aging. 76, pp. 45-52. https://doi.org/10.1016/j.neurobiolaging.2018.12.008
Apolipoprotein E4 mediates the association between midlife dyslipidemia and cerebral amyloid in aging women
Szoeke, Cassandra, Goodwill, Alicia M., Gorelik, Alexandra, Dennerstein, Lorraine, Caeyenberghs, Karen, Simpson, Steve, Hill, Edward and Campbell, Stephen. (2019). Apolipoprotein E4 mediates the association between midlife dyslipidemia and cerebral amyloid in aging women. Journal of Alzheimer's Disease. 68(1), pp. 105 - 114. https://doi.org/10.3233/JAD-180815