Inflammation and metabolism : The role of adiposity in sarcopenic obesity

Conference paper


Lynch, G. M., Murphy, C. H., Castro, E. de Marco and Roche, H. M.. (2020) Inflammation and metabolism : The role of adiposity in sarcopenic obesity. The 13th European Nutrition Conference (FENS 2019). Dublin, Ireland 15 - 18 Oct 2019 Cambridge University Press. pp. 435-447 https://doi.org/10.1017/S0029665120007119
AuthorsLynch, G. M., Murphy, C. H., Castro, E. de Marco and Roche, H. M.
TypeConference paper
Abstract

Sarcopenic obesity is characterised by the double burden of diminished skeletal muscle mass and the presence of excess adiposity. From a mechanistic perspective, both obesity and sarcopenia are associated with sub-acute, chronic pro-inflammatory states that impede metabolic processes, disrupting adipose and skeletal functionality, which may potentiate disease. Recent evidence suggests that there is an important cross-talk between metabolism and inflammation, which has shifted focus upon metabolic-inflammation as a key emerging biological interaction. Dietary intake, physical activity and nutritional status are important environmental factors that may modulate metabolic-inflammation. This paradigm will be discussed within the context of sarcopenic obesity risk. There is a paucity of data in relation to the nature and the extent to which nutritional status affects metabolic-inflammation in sarcopenic obesity. Research suggests that there may be scope for the modulation of sarcopenic obesity with alterations in diet. The potential impact of increasing protein consumption and reconfiguration of dietary fat composition in human dietary interventions are evaluated. This review will explore emerging data with respect to if and how different dietary components may modulate metabolic-inflammation, particularly with respect to adiposity, within the context of sarcopenic obesity.

Keywordsadipose; obesity; sarcopenia; lipotoxicity; inflammation; anabolic resistance; adipose tissue macrophage; C-reactive protein; forkhead box O; insulin resistance; long chain; muscle protein breakdown; muscle protein synthesis; type 2 diabetes
Year2020
JournalProceedings of the Nutrition Society
PublisherCambridge University Press
ISSN0029-6651
1475-2719
Digital Object Identifier (DOI)https://doi.org/10.1017/S0029665120007119
Scopus EID2-s2.0-85094105505
Research or scholarlyResearch
Publisher's version
License
All rights reserved
File Access Level
Controlled
Journal citation79 (4), pp. 435-447
Page range435-447
Output statusPublished
Publication dates
Online20 Aug 2020
Publication process dates
Deposited22 Jun 2021
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