Central markers of neuroinflammation in alcohol use disorder : A meta-analysis of neuroimaging, cerebral spinal fluid, and postmortem studies

Journal article

Adams, Claire, Perry, Nina, Conigrave, James, Hurzeler, Tristan, Stevens, Julia, Yacou Dunbar, Kristiane P., Sweeney, Alicia, Lee, K. S. Kylie, Sutherland, Greg, Haber, Paul and Morley, Kirsten C.. (2023). Central markers of neuroinflammation in alcohol use disorder : A meta-analysis of neuroimaging, cerebral spinal fluid, and postmortem studies. Alcoholism : Clinical and Experimental Research. 47(2), pp. 197-208. https://doi.org/10.1111/acer.14992
AuthorsAdams, Claire, Perry, Nina, Conigrave, James, Hurzeler, Tristan, Stevens, Julia, Yacou Dunbar, Kristiane P., Sweeney, Alicia, Lee, K. S. Kylie, Sutherland, Greg, Haber, Paul and Morley, Kirsten C.
Abstract

Introduction and aims: There is emerging evidence that heavy long-term alcohol consumption may alter the neuroimmune profile. We conducted a meta-analysis of the association between alcohol use disorder (AUD) and the extent of neuroinflammation using cerebrospinal (CSF), PET (Positron Emission Tomography), and postmortem studies.

Design and methods: A comprehensive search of electronic databases was conducted using the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) for AUD-related terms in combination with neuroinflammatory markers and cytokine- and chemokine-related terms for CSF, PET, and postmortem studies. Participants had to meet established criteria for AUD and/or heavy alcohol consumption with dependence features and be compared with healthy controls. Papers retrieved were assessed for inclusion criteria and a critical appraisal was completed using the Newcastle-Ottawa Scale. A meta-analysis was conducted on postmortem and PET studies.

Results: Eleven papers met the inclusion criteria with CSF, PET, and postmortem studies included in the final analysis. Postmortem studies demonstrate significant heterogeneity (𝑄 (14) = 62.02, 𝑝 < 0.001), with the alcohol group showing higher levels of neuroimmune markers than controls (𝑑 = 1.50 [95% CI 0.56, 2.45]). PET studies demonstrated a lower [11C] PBR28 total volume of distribution (V T) for translocator protein in the hippocampus (g = βˆ’1.95 [95% CI βˆ’2.72, βˆ’1.18], p < 0.001) of the alcohol group compared to controls.

Conclusion: There is emerging evidence across multiple diagnostic modalities that alcohol impacts neuroimmune signaling in the human brain.

Keywordsalcohol dependence; alcohol use disorder; neuroimaging; neuroinflammation
Year01 Jan 2023
JournalAlcoholism : Clinical and Experimental Research
Journal citation47 (2), pp. 197-208
PublisherWiley-Blackwell Publishing, Inc. (US)
ISSN0145-6008
Digital Object Identifier (DOI)https://doi.org/10.1111/acer.14992
Web address (URL)https://onlinelibrary.wiley.com/doi/10.1111/acer.14992
Open accessPublished as non-open access
Research or scholarlyResearch
Page range197-208
Publisher's version
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All rights reserved
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Controlled
Output statusPublished
Publication dates
Print28 Feb 2023
Publication process dates
Accepted30 Nov 2022
Deposited22 Jul 2024
Additional information

Β© 2023 Research Society on Alcohol.

Place of publicationUnited States
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