Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study

Journal article


Eleni P Ganella, Caio Seguin, Christos Pantelis, Sarah Whittle, Bernhard T Baune, James Olver, G Paul Amminger, Patrick D. McGorry, Vanessa L. Cropley, Andrew Zalesky and Cali F Bartholomeusz. (2018). Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study. Australian and New Zealand Journal of Psychiatry. 52(9), pp. 864-875. https://doi.org/10.1177/0004867418775833
AuthorsEleni P Ganella, Caio Seguin, Christos Pantelis, Sarah Whittle, Bernhard T Baune, James Olver, G Paul Amminger, Patrick D. McGorry, Vanessa L. Cropley, Andrew Zalesky and Cali F Bartholomeusz
Abstract

Introduction:
Schizophrenia is increasingly conceived as a disorder of brain network connectivity and organization. However, reports of network abnormalities during the early illness stage of psychosis are mixed. This study adopted a data-driven whole-brain approach to investigate functional connectivity and network architecture in a first-episode psychosis cohort relative to healthy controls and whether functional network properties changed abnormally over a 12-month period in first-episode psychosis.

Methods:
Resting-state functional connectivity was performed at two time points. At baseline, 29 first-episode psychosis individuals and 30 healthy controls were assessed, and at 12 months, 14 first-episode psychosis individuals and 20 healthy controls completed follow-up. Whole-brain resting-state functional connectivity networks were mapped for each individual and analyzed using graph theory to investigate whether network abnormalities associated with first-episode psychosis were evident and whether functional network properties changed abnormally over 12 months relative to controls.

Results:
This study found no evidence of abnormal resting-state functional connectivity or topology in first-episode psychosis individuals relative to healthy controls at baseline or at 12-months follow-up. Furthermore, longitudinal changes in network properties over a 12-month period did not significantly differ between first-episode psychosis individuals and healthy control. Network measures did not significantly correlate with symptomatology, duration of illness or antipsychotic medication.

Conclusions:
This is the first study to show unaffected resting-state functional connectivity and topology in the early psychosis stage of illness. In light of previous literature, this suggests that a subgroup of first-episode psychosis individuals who have a neurotypical resting-state functional connectivity and topology may exist. Our preliminary longitudinal analyses indicate that there also does not appear to be deterioration in these network properties over a 12-month period. Future research in a larger sample is necessary to confirm our longitudinal findings.

Keywordsresting state; first episode of psychosis; functional connectivity; graph theory
Year2018
JournalAustralian and New Zealand Journal of Psychiatry
Journal citation52 (9), pp. 864-875
PublisherSAGE Publications Inc.
ISSN0004-8674
Digital Object Identifier (DOI)https://doi.org/10.1177/0004867418775833
Scopus EID2-s2.0-85047662098
Publisher's version
File Access Level
Controlled
Publication process dates
Deposited13 May 2021
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