Linking cortical and connectional pathology in Schizophrenia

Journal article


Di Biase, Maria Angelique, Cropley, Vanessa L., Cocchi, Luca, Fornito, Alexander, Calamante, Fernando, Ganella, Eleni P., Pantelis, Christos and Zalesky, Andrew. (2019). Linking cortical and connectional pathology in Schizophrenia. Schizophrenia Bulletin. 45(4), pp. 911-923. https://doi.org/10.1093/schbul/sby121
AuthorsDi Biase, Maria Angelique, Cropley, Vanessa L., Cocchi, Luca, Fornito, Alexander, Calamante, Fernando, Ganella, Eleni P., Pantelis, Christos and Zalesky, Andrew
Abstract

Schizophrenia is associated with cortical thickness (CT) deficits and breakdown in white matter microstructure. Whether these pathological processes are related remains unclear. We used multimodal neuroimaging to investigate the relationship between regional cortical thinning and breakdown in adjacent infracortical white matter as a function of age and illness duration. Structural magnetic resonance and diffusion images were acquired in 218 schizophrenia patients and 167 age-matched healthy controls to map CT and fractional anisotropy in regionally adjacent infracortical white matter at various cortical depths. We found a robust and reproducible relationship between thickness and anisotropy deficits, which were inversely correlated across cortical regions (r = −.5, P < .0001): the most anisotropic infracortical white matter was found adjacent to regions with extensive cortical thinning. This pattern was evident in early (20 y: r = −.3, P = .005) and middle life (30 y: r = −.4, P = .004, 40 y: r = −.3, P = .04), but not beyond 50 years (P > .05). Frontal pathology contributed most to this pattern, with cortical thinning in patients compared to controls at all ages (P < .05); in contrast to initially elevated frontal white matter anisotropy in patients at 30 years, followed by rapid white matter decline with age (rate of annual decline; patients: 0.0012, controls 0.0006, P < .001). Our findings point to pathological dependencies between gray and white matter in a large sample of schizophrenia patients. We argue that elevated frontal anisotropy reflects regionally-specific, compensatory responses to cortical thinning, which are eventually overwhelmed with increasing illness duration.

Keywordsneuropsychiatry; multimodal imaging; computational psychiatry; cortical thickness; diffusion; tractography
Year2019
JournalSchizophrenia Bulletin
Journal citation45 (4), pp. 911-923
PublisherNLM (Medline)
ISSN0586-7614
Digital Object Identifier (DOI)https://doi.org/10.1093/schbul/sby121
Scopus EID2-s2.0-85068431356
Research or scholarlyResearch
Page range911-923
FunderAustralian Research Council (ARC)
National Health and Medical Research Council (NHMRC)
Publisher's version
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All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online12 Sep 2018
Publication process dates
Deposited11 Jul 2021
ARC Funded ResearchThis output has been funded, wholly or partially, under the Australian Research Council Act 2001
Grant IDARC/FT130100589
NHMRC/386500
NHMRC/628880
NHMRC/1099082
NHMRC/1138711
NHMRC/628386
NHMRC/1105825
NHMRC/1047648
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